BK virus infection and outcome following kidney transplantation in childhood
Authors
McCaffrey, James
Bhute, Vijesh J.
Shenoy, Mohan
Publication Date
2021-01-28Journal Title
Scientific Reports
Publisher
Nature Publishing Group UK
Volume
11
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
McCaffrey, J., Bhute, V. J., & Shenoy, M. (2021). BK virus infection and outcome following kidney transplantation in childhood. Scientific Reports, 11 (1) https://doi.org/10.1038/s41598-021-82160-0
Abstract
Abstract: BK virus associated nephropathy (BKN) is an important cause of kidney allograft failure. In a cohort of paediatric kidney transplant recipients, we aimed to understand the incidence and clinical outcome associated with BKN, as well as identify risk factors for BKN and BK viraemia development. We retrospectively analysed all patients who received a kidney transplant and received follow up care in our centre between 2009–2019. Among 106 patients included in the study (mean follow up 4.5 years), 32/106 (30.2%) patients experienced BK viraemia. The incidence of BKN was 7/106 (6.6%). The median time of BK viraemia development post-transplant was 279.5 days compared to 90.0 days for BKN. Development of BKN was associated with younger age at transplantation (p = 0.013). Development of BK viraemia was associated with negative recipient serology for cytomegalovirus (CMV) at time of transplantation (p = 0.012) and a higher net level of immunosuppression (p = 0.039). There was no difference in graft function at latest follow up between those who experienced BKN and those without BKN. This study demonstrates that BK virus infection is associated with younger age at transplantation, CMV negative recipient serostatus and higher levels of immunosuppression. Judicious monitoring of BK viraemia in paediatric transplant recipients, coupled with timely clinical intervention can result in similar long-term outcomes for BKN patients compared to controls.
Keywords
Article, /692/699/1585/2762, /692/420/254, /692/4022/272, /692/4022/1585, /692/4022/1950, /692/699/255/2514, /692/699/255, /692/699/1585, article
Sponsorship
Pathological Society of Great Britain and Ireland (JSPS CLG 2019 02)
Jean Shanks Foundation (JSPS CLG 2019 02)
Identifiers
s41598-021-82160-0, 82160
External DOI: https://doi.org/10.1038/s41598-021-82160-0
This record's URL: https://www.repository.cam.ac.uk/handle/1810/316823
Rights
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/
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