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dc.contributor.authorMcCaffrey, James
dc.contributor.authorBhute, Vijesh J.
dc.contributor.authorShenoy, Mohan
dc.date.accessioned2021-01-28T16:14:02Z
dc.date.available2021-01-28T16:14:02Z
dc.date.issued2021-01-28
dc.date.submitted2020-11-10
dc.identifier.others41598-021-82160-0
dc.identifier.other82160
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/316823
dc.description.abstractAbstract: BK virus associated nephropathy (BKN) is an important cause of kidney allograft failure. In a cohort of paediatric kidney transplant recipients, we aimed to understand the incidence and clinical outcome associated with BKN, as well as identify risk factors for BKN and BK viraemia development. We retrospectively analysed all patients who received a kidney transplant and received follow up care in our centre between 2009–2019. Among 106 patients included in the study (mean follow up 4.5 years), 32/106 (30.2%) patients experienced BK viraemia. The incidence of BKN was 7/106 (6.6%). The median time of BK viraemia development post-transplant was 279.5 days compared to 90.0 days for BKN. Development of BKN was associated with younger age at transplantation (p = 0.013). Development of BK viraemia was associated with negative recipient serology for cytomegalovirus (CMV) at time of transplantation (p = 0.012) and a higher net level of immunosuppression (p = 0.039). There was no difference in graft function at latest follow up between those who experienced BKN and those without BKN. This study demonstrates that BK virus infection is associated with younger age at transplantation, CMV negative recipient serostatus and higher levels of immunosuppression. Judicious monitoring of BK viraemia in paediatric transplant recipients, coupled with timely clinical intervention can result in similar long-term outcomes for BKN patients compared to controls.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/692/699/1585/2762
dc.subject/692/420/254
dc.subject/692/4022/272
dc.subject/692/4022/1585
dc.subject/692/4022/1950
dc.subject/692/699/255/2514
dc.subject/692/699/255
dc.subject/692/699/1585
dc.subjectarticle
dc.titleBK virus infection and outcome following kidney transplantation in childhood
dc.typeArticle
dc.date.updated2021-01-28T16:14:01Z
prism.issueIdentifier1
prism.publicationNameScientific Reports
prism.volume11
dc.identifier.doi10.17863/CAM.63938
dcterms.dateAccepted2021-01-14
rioxxterms.versionofrecord10.1038/s41598-021-82160-0
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2045-2322
pubs.funder-project-idPathological Society of Great Britain and Ireland (JSPS CLG 2019 02)
pubs.funder-project-idJean Shanks Foundation (JSPS CLG 2019 02)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)