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dc.contributor.authorMeek, Claire L.
dc.contributor.authorCorcoy, Rosa
dc.contributor.authorAsztalos, Elizabeth
dc.contributor.authorKusinski, Laura C.
dc.contributor.authorLópez, Esther
dc.contributor.authorFeig, Denice S.
dc.contributor.authorMurphy, Helen R.
dc.contributor.authorAsztalos, Elisabeth
dc.contributor.authorBarrett, Jon F. R.
dc.contributor.authorde Leiva, Alberto
dc.contributor.authorDonovan, Lois E.
dc.contributor.authorHod, J. Moshe
dc.contributor.authorJovanovic, Lois
dc.contributor.authorKeely, Erin
dc.contributor.authorKollman, Craig
dc.contributor.authorMcManus, Ruth
dc.contributor.authorMurphy, Kellie E.
dc.contributor.authorRuedy, Katrina
dc.contributor.authorTomlinson, George
dc.date.accessioned2021-01-29T17:21:17Z
dc.date.available2021-01-29T17:21:17Z
dc.date.issued2021-01-29
dc.date.submitted2020-05-13
dc.identifier.others12884-021-03554-6
dc.identifier.other3554
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/316862
dc.description.abstractAbstract: Background: Offspring of women with type 1 diabetes are at increased risk of fetal growth patterns which are associated with perinatal morbidity. Our aim was to compare rates of large- and small-for-gestational age (LGA; SGA) defined according to different criteria, using data from the Continuous Glucose Monitoring in Type 1 Diabetes Pregnancy Trial (CONCEPTT). Methods: This was a pre-specified analysis of CONCEPTT involving 225 pregnant women and liveborn infants from 31 international centres (ClinicalTrials.gov NCT01788527; registered 11/2/2013). Infants were weighed immediately at birth and GROW, INTERGROWTH and WHO centiles were calculated. Relative risk ratios, sensitivity and specificity were used to assess the different growth standards with respect to perinatal outcomes, including neonatal hypoglycaemia, hyperbilirubinaemia, respiratory distress, neonatal intensive care unit (NICU) admission and a composite neonatal outcome. Results: Accelerated fetal growth was common, with mean birthweight percentiles of 82.1, 85.7 and 63.9 and LGA rates of 62, 67 and 30% using GROW, INTERGROWTH and WHO standards respectively. Corresponding rates of SGA were 2.2, 1.3 and 8.9% respectively. LGA defined according to GROW centiles showed stronger associations with preterm delivery, neonatal hypoglycaemia, hyperbilirubinaemia and NICU admission. Infants born > 97.7th centile were at highest risk of complications. SGA defined according to INTERGROWTH centiles showed slightly stronger associations with perinatal outcomes. Conclusions: GROW and INTERGROWTH standards performed similarly and identified similar numbers of neonates with LGA and SGA. GROW-defined LGA and INTERGROWTH-defined SGA had slightly stronger associations with neonatal complications. WHO standards underestimated size in preterm infants and are less applicable for use in type 1 diabetes. Trial registration: This trial is registered with ClinicalTrials.gov. number NCT01788527. Trial registered 11/2/2013.
dc.languageen
dc.publisherBioMed Central
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectResearch Article
dc.subjectMaternal health and pregnancy
dc.subjectLarge-for-gestational-age
dc.subjectSmall for gestational age
dc.subjectMacrosomia
dc.subjectBirth-weight
dc.subjectDiabetes
dc.subjectPregnancy
dc.subjectCONCEPTT
dc.subjectGrowth standards
dc.subjectINTERGROWTH
dc.subjectGROW
dc.titleWhich growth standards should be used to identify large- and small-for-gestational age infants of mothers with type 1 diabetes? A pre-specified analysis of the CONCEPTT trial
dc.typeArticle
dc.date.updated2021-01-29T17:21:16Z
prism.issueIdentifier1
prism.publicationNameBMC Pregnancy and Childbirth
prism.volume21
dc.identifier.doi10.17863/CAM.63975
dcterms.dateAccepted2021-01-12
rioxxterms.versionofrecord10.1186/s12884-021-03554-6
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidMeek, Claire L. [0000-0002-4176-8329]
dc.identifier.eissn1471-2393
pubs.funder-project-idJuvenile Diabetes Research Foundation United Kingdom (GB) (17‐2011‐533)
pubs.funder-project-idJuvenile Diabetes Research Foundation Canada (80‐2010‐585)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)