Reproducibility of magnetic resonance fingerprinting-based T 1 mapping of the healthy prostate at 1.5 and 3.0 T: A proof-of-concept study
Kaggie, Joshua D.
Slough, Rhys A.
Public Library of Science
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Sushentsev, N., Kaggie, J. D., Slough, R. A., Carmo, B., & Barrett, T. (2021). Reproducibility of magnetic resonance fingerprinting-based T 1 mapping of the healthy prostate at 1.5 and 3.0 T: A proof-of-concept study. PLOS ONE, 16 (1) https://doi.org/10.1371/journal.pone.0245970
Funder: Cancer Research UK; funder-id: http://dx.doi.org/10.13039/501100000289
Funder: National Institute of Health Research Cambridge Biomedical Research Centre
Funder: Cancer Research UK and the Engineering and Physical Sciences Research Council Imaging Centre in Cambridge and Manchester
Funder: Cambridge Experimental Cancer Medicine Centre
Facilitating clinical translation of quantitative imaging techniques has been suggested as means of improving interobserver agreement and diagnostic accuracy of multiparametric magnetic resonance imaging (mpMRI) of the prostate. One such technique, magnetic resonance fingerprinting (MRF), has significant competitive advantages over conventional mapping techniques in terms of its multi-site reproducibility, short scanning time and inherent robustness to motion. It has also been shown to improve the detection of clinically significant prostate cancer when added to standard mpMRI sequences, however, the existing studies have all been conducted on 3.0 T MRI systems, limiting the technique’s use on 1.5 T MRI scanners that are still more widely used for prostate imaging across the globe. The aim of this proof-of-concept study was, therefore, to evaluate the cross-system reproducibility of prostate MRF T1 in healthy volunteers (HVs) using 1.5 and 3.0 T MRI systems. The initial validation of MRF T1 against gold standard inversion recovery fast spin echo (IR-FSE) T1 in the ISMRM/NIST MRI system revealed a strong linear correlation between phantom-derived MRF and IR-FSE T1 values was observed at both field strengths (R2 = 0.998 at 1.5T and R2 = 0.993 at 3T; p = < 0.0001 for both). In young HVs, inter-scanner CVs demonstrated marginal differences across all tissues with the highest difference of 3% observed in fat (2% at 1.5T vs 5% at 3T). At both field strengths, MRF T1 could confidently differentiate prostate peripheral zone from transition zone, which highlights the high quantitative potential of the technique given the known difficulty of tissue differentiation in this age group. The high cross-system reproducibility of MRF T1 relaxometry of the healthy prostate observed in this preliminary study, therefore, supports the technique’s prospective clinical validation as part of larger trials employing 1.5 T MRI systems, which are still widely used clinically for routine mpMRI of the prostate.
Research Article, Biology and life sciences, Medicine and health sciences, Research and analysis methods, Physical sciences
External DOI: https://doi.org/10.1371/journal.pone.0245970
This record's URL: https://www.repository.cam.ac.uk/handle/1810/316901
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/