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dc.contributor.authorYetsko, Kelsey
dc.contributor.authorFarrell, Jessica A.
dc.contributor.authorBlackburn, Nicholas B.
dc.contributor.authorWhitmore, Liam
dc.contributor.authorStammnitz, Maximilian R.
dc.contributor.authorWhilde, Jenny
dc.contributor.authorEastman, Catherine B.
dc.contributor.authorRamia, Devon Rollinson
dc.contributor.authorThomas, Rachel
dc.contributor.authorKrstic, Aleksandar
dc.contributor.authorLinser, Paul
dc.contributor.authorCreer, Simon
dc.contributor.authorCarvalho, Gary
dc.contributor.authorDevlin, Mariana A.
dc.contributor.authorNahvi, Nina
dc.contributor.authorLeandro, Ana Cristina
dc.contributor.authordeMaar, Thomas W.
dc.contributor.authorBurkhalter, Brooke
dc.contributor.authorMurchison, Elizabeth P.
dc.contributor.authorSchnitzler, Christine
dc.contributor.authorDuffy, David J.
dc.date.accessioned2021-02-01T16:06:41Z
dc.date.available2021-02-01T16:06:41Z
dc.date.issued2021-02-01
dc.date.submitted2020-06-03
dc.identifier.others42003-021-01656-7
dc.identifier.other1656
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/316930
dc.description.abstractAbstract: Sea turtle populations are under threat from an epizootic tumor disease (animal epidemic) known as fibropapillomatosis. Fibropapillomatosis continues to spread geographically, with prevalence of the disease also growing at many longer-affected sites globally. However, we do not yet understand the precise environmental, mutational and viral events driving fibropapillomatosis tumor formation and progression. Here we perform transcriptomic and immunohistochemical profiling of five fibropapillomatosis tumor types: external new, established and postsurgical regrowth tumors, and internal lung and kidney tumors. We reveal that internal tumors are molecularly distinct from the more common external tumors. However, they have a small number of conserved potentially therapeutically targetable molecular vulnerabilities in common, such as the MAPK, Wnt, TGFβ and TNF oncogenic signaling pathways. These conserved oncogenic drivers recapitulate remarkably well the core pan-cancer drivers responsible for human cancers. Fibropapillomatosis has been considered benign, but metastatic-related transcriptional signatures are strongly activated in kidney and established external tumors. Tumors in turtles with poor outcomes (died/euthanized) have genes associated with apoptosis and immune function suppressed, with these genes providing putative predictive biomarkers. Together, these results offer an improved understanding of fibropapillomatosis tumorigenesis and provide insights into the origins, inter-tumor relationships, and therapeutic treatment for this wildlife epizootic.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/67
dc.subject/631/158
dc.subject/631/67/69
dc.subject/631/67/70
dc.subject/631/158/672
dc.subject/38/1
dc.subject/38/39
dc.subject/38/91
dc.subject/45
dc.subject/96/95
dc.subjectarticle
dc.titleMolecular characterization of a marine turtle tumor epizootic, profiling external, internal and postsurgical regrowth tumors
dc.typeArticle
dc.date.updated2021-02-01T16:06:39Z
prism.issueIdentifier1
prism.publicationNameCommunications Biology
prism.volume4
dc.identifier.doi10.17863/CAM.64043
dcterms.dateAccepted2020-12-31
rioxxterms.versionofrecord10.1038/s42003-021-01656-7
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidFarrell, Jessica A. [0000-0003-2303-7204]
dc.contributor.orcidBlackburn, Nicholas B. [0000-0002-9774-1539]
dc.contributor.orcidStammnitz, Maximilian R. [0000-0002-1704-9199]
dc.contributor.orcidCreer, Simon [0000-0003-3124-3550]
dc.contributor.orcidSchnitzler, Christine [0000-0002-5001-6524]
dc.contributor.orcidDuffy, David J. [0000-0002-6075-8855]
dc.identifier.eissn2399-3642
pubs.funder-project-idUniversity of Cambridge (Gates Cambridge PhD scholarship)
pubs.funder-project-idSea Turtle Conservancy (STC) (17-033R)
pubs.funder-project-idSave Our Seas Foundation (SOSF) (SOSF 356)
pubs.funder-project-idEC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) (663830-BU115)
pubs.funder-project-idIrish Research Council for Science, Engineering and Technology (IRCSET) (GOIPG/2020/1056)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)