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dc.contributor.authorReiman, Eric M.
dc.contributor.authorArboleda-Velasquez, Joseph F.
dc.contributor.authorQuiroz, Yakeel T.
dc.contributor.authorHuentelman, Matthew J.
dc.contributor.authorBeach, Thomas G.
dc.contributor.authorCaselli, Richard J.
dc.contributor.authorChen, Yinghua
dc.contributor.authorSu, Yi
dc.contributor.authorMyers, Amanda J.
dc.contributor.authorHardy, John
dc.contributor.authorPaul Vonsattel, Jean
dc.contributor.authorYounkin, Steven G.
dc.contributor.authorBennett, David A.
dc.contributor.authorDe Jager, Philip L.
dc.contributor.authorLarson, Eric B.
dc.contributor.authorCrane, Paul K.
dc.contributor.authorKeene, C. Dirk
dc.contributor.authorKamboh, M. Ilyas
dc.contributor.authorKofler, Julia K.
dc.contributor.authorDuque, Linda
dc.contributor.authorGilbert, John R.
dc.contributor.authorGwirtsman, Harry E.
dc.contributor.authorBuxbaum, Joseph D.
dc.contributor.authorDickson, Dennis W.
dc.contributor.authorFrosch, Matthew P.
dc.contributor.authorGhetti, Bernardino F.
dc.contributor.authorLunetta, Kathryn L.
dc.contributor.authorWang, Li-San
dc.contributor.authorHyman, Bradley T.
dc.contributor.authorKukull, Walter A.
dc.contributor.authorForoud, Tatiana
dc.contributor.authorHaines, Jonathan L.
dc.contributor.authorMayeux, Richard P.
dc.contributor.authorPericak-Vance, Margaret A.
dc.contributor.authorSchneider, Julie A.
dc.contributor.authorTrojanowski, John Q.
dc.contributor.authorFarrer, Lindsay A.
dc.contributor.authorSchellenberg, Gerard D.
dc.contributor.authorBeecham, Gary W.
dc.contributor.authorMontine, Thomas J.
dc.contributor.authorJun, Gyungah R.
dc.contributor.authorAbner, Erin
dc.contributor.authorAdams, Perrie M.
dc.contributor.authorAlbert, Marilyn S.
dc.contributor.authorAlbin, Roger L.
dc.contributor.authorApostolova, Liana G.
dc.contributor.authorArnold, Steven E.
dc.contributor.authorAsthana, Sanjay
dc.contributor.authorAtwood, Craig S.
dc.contributor.authorBaldwin, Clinton T.
dc.contributor.authorBarber, Robert C.
dc.contributor.authorBarnes, Lisa L.
dc.contributor.authorBarral, Sandra
dc.contributor.authorBecker, James T.
dc.contributor.authorBeekly, Duane
dc.contributor.authorBigio, Eileen H.
dc.contributor.authorBird, Thomas D.
dc.contributor.authorBlacker, Deborah
dc.contributor.authorBoeve, Bradley F.
dc.contributor.authorBowen, James D.
dc.contributor.authorBoxer, Adam
dc.contributor.authorBurke, James R.
dc.contributor.authorBurns, Jeffrey M.
dc.contributor.authorCairns, Nigel J.
dc.contributor.authorCantwell, Laura B.
dc.contributor.authorCao, Chuanhai
dc.contributor.authorCarlson, Chris S.
dc.contributor.authorCarlsson, Cynthia M.
dc.contributor.authorCarney, Regina M.
dc.contributor.authorCarrasquillo, Minerva M.
dc.contributor.authorChui, Helena C.
dc.contributor.authorCribbs, David H.
dc.contributor.authorCrocco, Elizabeth A.
dc.contributor.authorCruchaga, Carlos
dc.contributor.authorDeCarli, Charles
dc.contributor.authorDick, Malcolm
dc.contributor.authorDoody, Rachelle S.
dc.contributor.authorDuara, Ranjan
dc.contributor.authorErtekin-Taner, Nilufer
dc.contributor.authorEvans, Denis A.
dc.contributor.authorFaber, Kelley M.
dc.contributor.authorFairchild, Thomas J.
dc.contributor.authorFallon, Kenneth B.
dc.contributor.authorFardo, David W.
dc.contributor.authorFarlow, Martin R.
dc.contributor.authorFerris, Steven
dc.contributor.authorGalasko, Douglas R.
dc.contributor.authorGearing, Marla
dc.contributor.authorGeschwind, Daniel H.
dc.contributor.authorGhisays, Valentina
dc.contributor.authorGoate, Alison M.
dc.contributor.authorGraff-Radford, Neill R.
dc.contributor.authorGreen, Robert C.
dc.contributor.authorGrowdon, John H.
dc.contributor.authorHakonarson, Hakon
dc.contributor.authorHamilton, Ronald L.
dc.contributor.authorHamilton-Nelson, Kara L.
dc.contributor.authorHarrell, Lindy E.
dc.contributor.authorHonig, Lawrence S.
dc.contributor.authorHuebinger, Ryan M.
dc.contributor.authorHulette, Christine M.
dc.contributor.authorJarvik, Gail P.
dc.contributor.authorJin, Lee-Way
dc.contributor.authorKarydas, Anna
dc.contributor.authorKatz, Mindy J.
dc.contributor.authorKauwe, John S. K.
dc.contributor.authorKaye, Jeffrey A.
dc.contributor.authorKim, Ronald
dc.contributor.authorKowall, Neil W.
dc.contributor.authorKramer, Joel H.
dc.contributor.authorKunkle, Brian W.
dc.contributor.authorKuzma, Amanda P.
dc.contributor.authorLaFerla, Frank M.
dc.contributor.authorLah, James J.
dc.contributor.authorLeung, Yuk Ye
dc.contributor.authorLeverenz, James B.
dc.contributor.authorLevey, Allan I.
dc.contributor.authorLi, Ge
dc.contributor.authorLieberman, Andrew P.
dc.contributor.authorLipton, Richard B.
dc.contributor.authorLopez, Oscar L.
dc.contributor.authorLyketsos, Constantine G.
dc.contributor.authorMalamon, John
dc.contributor.authorMarson, Daniel C.
dc.contributor.authorMartin, Eden R.
dc.contributor.authorMartiniuk, Frank
dc.contributor.authorMash, Deborah C.
dc.contributor.authorMasliah, Eliezer
dc.contributor.authorMcCormick, Wayne C.
dc.contributor.authorMcCurry, Susan M.
dc.contributor.authorMcDavid, Andrew N.
dc.contributor.authorMcDonough, Stefan
dc.contributor.authorMcKee, Ann C.
dc.contributor.authorMesulam, Marsel
dc.contributor.authorMiller, Bruce L.
dc.contributor.authorMiller, Carol A.
dc.contributor.authorMiller, Joshua W.
dc.contributor.authorMorris, John C.
dc.contributor.authorMukherjee, Shubhabrata
dc.contributor.authorNaj, Adam C.
dc.contributor.authorO’Bryant, Sid
dc.contributor.authorOlichney, John M.
dc.contributor.authorParisi, Joseph E.
dc.contributor.authorPaulson, Henry L.
dc.contributor.authorPeskind, Elaine
dc.contributor.authorPetersen, Ronald C.
dc.contributor.authorPierce, Aimee
dc.contributor.authorPoon, Wayne W.
dc.contributor.authorPotter, Huntington
dc.contributor.authorQu, Liming
dc.contributor.authorQuinn, Joseph F.
dc.contributor.authorRaj, Ashok
dc.contributor.authorRaskind, Murray
dc.contributor.authorReisberg, Barry
dc.contributor.authorReisch, Joan S.
dc.contributor.authorReitz, Christiane
dc.contributor.authorRingman, John M.
dc.contributor.authorRoberson, Erik D.
dc.contributor.authorRogaeva, Ekaterina
dc.contributor.authorRosen, Howard J.
dc.contributor.authorRosenberg, Roger N.
dc.contributor.authorRoyall, Donald R.
dc.contributor.authorSager, Mark A.
dc.contributor.authorSano, Mary
dc.contributor.authorSaykin, Andrew J.
dc.contributor.authorSchneider, Lon S.
dc.contributor.authorSeeley, William W.
dc.contributor.authorSmith, Amanda G.
dc.contributor.authorSonnen, Joshua A.
dc.contributor.authorSpina, Salvatore
dc.contributor.authorGeorge-Hyslop, Peter St
dc.contributor.authorStern, Robert A.
dc.contributor.authorSwerdlow, Russell H.
dc.contributor.authorTanzi, Rudolph E.
dc.contributor.authorTroncoso, Juan C.
dc.contributor.authorTsuang, Debby W.
dc.contributor.authorValladares, Otto
dc.contributor.authorVan Deerlin, Vivianna M.
dc.contributor.authorVan Eldik, Linda J.
dc.contributor.authorVardarajan, Badri N.
dc.contributor.authorVinters, Harry V.
dc.contributor.authorWeintraub, Sandra
dc.contributor.authorWelsh-Bohmer, Kathleen A.
dc.contributor.authorWilhelmsen, Kirk C.
dc.contributor.authorWilliamson, Jennifer
dc.contributor.authorWingo, Thomas S.
dc.contributor.authorWoltjer, Randall L.
dc.contributor.authorWright, Clinton B.
dc.contributor.authorWu, Chuang-Kuo
dc.contributor.authorYu, Chang-En
dc.contributor.authorYu, Lei
dc.contributor.authorZhao, Yi
dc.date.accessioned2021-02-02T17:13:50Z
dc.date.available2021-02-02T17:13:50Z
dc.date.issued2020-02-03
dc.date.submitted2019-10-01
dc.identifier.others41467-019-14279-8
dc.identifier.other14279
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/317019
dc.description.abstractAbstract: Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer’s dementia, while the APOE2 allele is associated with a lower risk of Alzheimer’s dementia, it is not yet known whether APOE2 homozygotes have a particularly low risk. We generated Alzheimer’s dementia odds ratios and other findings in more than 5,000 clinically characterized and neuropathologically characterized Alzheimer’s dementia cases and controls. APOE2/2 was associated with a low Alzheimer’s dementia odds ratios compared to APOE2/3 and 3/3, and an exceptionally low odds ratio compared to APOE4/4, and the impact of APOE2 and APOE4 gene dose was significantly greater in the neuropathologically confirmed group than in more than 24,000 neuropathologically unconfirmed cases and controls. Finding and targeting the factors by which APOE and its variants influence Alzheimer’s disease could have a major impact on the understanding, treatment and prevention of the disease.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/378/1689/1283
dc.subject/692/308/2056
dc.subject/38/43
dc.subject/141
dc.subject/38/39
dc.subjectarticle
dc.titleExceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study
dc.typeArticle
dc.date.updated2021-02-02T17:13:49Z
prism.issueIdentifier1
prism.publicationNameNature Communications
prism.volume11
dc.identifier.doi10.17863/CAM.64130
dcterms.dateAccepted2019-12-19
rioxxterms.versionofrecord10.1038/s41467-019-14279-8
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidReiman, Eric M. [0000-0002-0705-3696]
dc.contributor.orcidArboleda-Velasquez, Joseph F. [0000-0002-3192-9117]
dc.contributor.orcidDickson, Dennis W. [0000-0001-7189-7917]
dc.contributor.orcidGhetti, Bernardino F. [0000-0002-1842-8019]
dc.contributor.orcidLunetta, Kathryn L. [0000-0002-9268-810X]
dc.contributor.orcidHyman, Bradley T. [0000-0002-7959-9401]
dc.contributor.orcidHaines, Jonathan L. [0000-0002-4351-4728]
dc.contributor.orcidPericak-Vance, Margaret A. [0000-0001-7283-8804]
dc.contributor.orcidTrojanowski, John Q. [0000-0002-9239-8794]
dc.contributor.orcidJun, Gyungah R. [0000-0002-3230-8697]
dc.identifier.eissn2041-1723
pubs.funder-project-idU.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) (RF1AG057519, P30-AG10161, R01AG15819, R01AG17917)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)