Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source.
The Journal of organic chemistry
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Lopatka, P., Markovič, M., Koóš, P., Ley, S., & Gracza, T. (2019). Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source.. The Journal of organic chemistry, 84 (22), 14394-14406. https://doi.org/10.1021/acs.joc.9b02453
This work discloses a continuous flow carbonylation reaction using iron pentacarbonyl as source of CO. The described transformation using this surrogate was designed for use in commonly accessible flow equipment. Optimized conditions were applied to a scalable synthesis of the natural compound isolated from perianal glandular pheromone secretion of the African civet cat. In addition, a flow Pd-catalyzed carbonylation of aryl halides is successfully reported.
Slovak Grant Agencies (APVV-14-0147 and VEGA o. 1/0552/18)
External DOI: https://doi.org/10.1021/acs.joc.9b02453
This record's URL: https://www.repository.cam.ac.uk/handle/1810/317045
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