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Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source.

Accepted version
Peer-reviewed

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Article

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Abstract

This work discloses a continuous flow carbonylation reaction using iron pentacarbonyl as source of CO. The described transformation using this surrogate was designed for use in commonly accessible flow equipment. Optimized conditions were applied to a scalable synthesis of the natural compound isolated from perianal glandular pheromone secretion of the African civet cat. In addition, a flow Pd-catalyzed carbonylation of aryl halides is successfully reported.

Description

Keywords

3405 Organic Chemistry, 34 Chemical Sciences

Journal Title

J Org Chem

Conference Name

Journal ISSN

0022-3263
1520-6904

Volume Title

84

Publisher

American Chemical Society (ACS)

Rights

All rights reserved
Sponsorship
Slovak Grant Agencies (APVV-14-0147 and VEGA o. 1/0552/18)