Microbleeds in dementia with Lewy bodies
Authors
Firbank, Michael
Mitra, Dipayan
Petrides, George
Lloyd, Jim
Barnett, Nicola
Olsen, Kirsty
Thomas, Alan J.
O’Brien, John T.
Publication Date
2020-02-04Journal Title
Journal of Neurology
ISSN
0340-5354
Publisher
Springer Berlin Heidelberg
Volume
267
Issue
5
Pages
1491-1498
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Donaghy, P. C., Firbank, M., Mitra, D., Petrides, G., Lloyd, J., Barnett, N., Olsen, K., et al. (2020). Microbleeds in dementia with Lewy bodies. Journal of Neurology, 267 (5), 1491-1498. https://doi.org/10.1007/s00415-020-09736-0
Description
Funder: Avid Radiopharmaceuticals; doi: http://dx.doi.org/10.13039/100014392
Abstract
Abstract: Introduction: Microbleeds are associated with the development of dementia in older people and are common in Alzheimer’s disease (AD). Their prevalence and clinical importance in dementia with Lewy bodies (DLB) is unclear. The objective of this study was to compare the rates of microbleeds in DLB with those in AD and healthy older people, and investigate associations between microbleeds and amyloid deposition, vascular risk and disease severity in DLB. Methods: DLB (n = 30), AD (n = 18) and control (n = 20) participants underwent clinical assessment at baseline and 1 year in this longitudinal observational study. 3T MRI (including T2* susceptibility weighted imaging) and florbetapir PET were carried out at baseline. Microbleeds were rated visually and a standardised uptake value ratio (SUVR) was calculated from florbetapir PET scans. Results: 40% of DLB subjects had microbleeds compared with 50% of AD and 15% of controls. Compared to DLB without microbleeds, those with microbleeds had higher systolic BP (156 ± 26 v. 135 ± 19 mmHg; p = 0.03), but did not have greater levels of vascular disease or amyloid deposition (SUVR 1.25 ± 0.24 v. 1.25 ± 0.22; p = 0.33). There was evidence of less severe dementia in DLB participants with microbleeds, but these differences may have been driven by a shorter disease duration in those with microbleeds. Conclusion: The presence of microbleeds in DLB is associated with higher blood pressure, but not with other measures of vascular disease or amyloid deposition. The relationship between microbleeds and clinical presentation remains unclear.
Keywords
Original Communication, Dementia with lewy bodies, Microbleeds, Imaging, Amyloid, Vascular
Sponsorship
NIHR Newcastle Biomedical Research Centre (BH120812)
Identifiers
s00415-020-09736-0, 9736
External DOI: https://doi.org/10.1007/s00415-020-09736-0
This record's URL: https://www.repository.cam.ac.uk/handle/1810/317085
Rights
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/
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