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dc.contributor.authorDonaghy, Paul C.
dc.contributor.authorFirbank, Michael
dc.contributor.authorMitra, Dipayan
dc.contributor.authorPetrides, George
dc.contributor.authorLloyd, Jim
dc.contributor.authorBarnett, Nicola
dc.contributor.authorOlsen, Kirsty
dc.contributor.authorThomas, Alan J.
dc.contributor.authorO’Brien, John T.
dc.date.accessioned2021-02-03T16:16:08Z
dc.date.available2021-02-03T16:16:08Z
dc.date.issued2020-02-04
dc.date.submitted2019-12-10
dc.identifier.issn0340-5354
dc.identifier.others00415-020-09736-0
dc.identifier.other9736
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/317085
dc.descriptionFunder: Avid Radiopharmaceuticals; doi: http://dx.doi.org/10.13039/100014392
dc.description.abstractAbstract: Introduction: Microbleeds are associated with the development of dementia in older people and are common in Alzheimer’s disease (AD). Their prevalence and clinical importance in dementia with Lewy bodies (DLB) is unclear. The objective of this study was to compare the rates of microbleeds in DLB with those in AD and healthy older people, and investigate associations between microbleeds and amyloid deposition, vascular risk and disease severity in DLB. Methods: DLB (n = 30), AD (n = 18) and control (n = 20) participants underwent clinical assessment at baseline and 1 year in this longitudinal observational study. 3T MRI (including T2* susceptibility weighted imaging) and florbetapir PET were carried out at baseline. Microbleeds were rated visually and a standardised uptake value ratio (SUVR) was calculated from florbetapir PET scans. Results: 40% of DLB subjects had microbleeds compared with 50% of AD and 15% of controls. Compared to DLB without microbleeds, those with microbleeds had higher systolic BP (156 ± 26 v. 135 ± 19 mmHg; p = 0.03), but did not have greater levels of vascular disease or amyloid deposition (SUVR 1.25 ± 0.24 v. 1.25 ± 0.22; p = 0.33). There was evidence of less severe dementia in DLB participants with microbleeds, but these differences may have been driven by a shorter disease duration in those with microbleeds. Conclusion: The presence of microbleeds in DLB is associated with higher blood pressure, but not with other measures of vascular disease or amyloid deposition. The relationship between microbleeds and clinical presentation remains unclear.
dc.languageen
dc.publisherSpringer Berlin Heidelberg
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectOriginal Communication
dc.subjectDementia with lewy bodies
dc.subjectMicrobleeds
dc.subjectImaging
dc.subjectAmyloid
dc.subjectVascular
dc.titleMicrobleeds in dementia with Lewy bodies
dc.typeArticle
dc.date.updated2021-02-03T16:16:08Z
prism.endingPage1498
prism.issueIdentifier5
prism.publicationNameJournal of Neurology
prism.startingPage1491
prism.volume267
dc.identifier.doi10.17863/CAM.64195
dcterms.dateAccepted2020-01-27
rioxxterms.versionofrecord10.1007/s00415-020-09736-0
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidDonaghy, Paul C. [0000-0001-7195-4846]
dc.identifier.eissn1432-1459
pubs.funder-project-idNIHR Newcastle Biomedical Research Centre (BH120812)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)