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dc.contributor.authorLähnemann, David
dc.contributor.authorKöster, Johannes
dc.contributor.authorSzczurek, Ewa
dc.contributor.authorMcCarthy, Davis J.
dc.contributor.authorHicks, Stephanie C.
dc.contributor.authorRobinson, Mark D.
dc.contributor.authorVallejos, Catalina A.
dc.contributor.authorCampbell, Kieran R.
dc.contributor.authorBeerenwinkel, Niko
dc.contributor.authorMahfouz, Ahmed
dc.contributor.authorPinello, Luca
dc.contributor.authorSkums, Pavel
dc.contributor.authorStamatakis, Alexandros
dc.contributor.authorAttolini, Camille Stephan-Otto
dc.contributor.authorAparicio, Samuel
dc.contributor.authorBaaijens, Jasmijn
dc.contributor.authorBalvert, Marleen
dc.contributor.authorBarbanson, Buys de
dc.contributor.authorCappuccio, Antonio
dc.contributor.authorCorleone, Giacomo
dc.contributor.authorDutilh, Bas E.
dc.contributor.authorFlorescu, Maria
dc.contributor.authorGuryev, Victor
dc.contributor.authorHolmer, Rens
dc.contributor.authorJahn, Katharina
dc.contributor.authorLobo, Thamar Jessurun
dc.contributor.authorKeizer, Emma M.
dc.contributor.authorKhatri, Indu
dc.contributor.authorKielbasa, Szymon M.
dc.contributor.authorKorbel, Jan O.
dc.contributor.authorKozlov, Alexey M.
dc.contributor.authorKuo, Tzu-Hao
dc.contributor.authorLelieveldt, Boudewijn P.F.
dc.contributor.authorMandoiu, Ion I.
dc.contributor.authorMarioni, John C.
dc.contributor.authorMarschall, Tobias
dc.contributor.authorMölder, Felix
dc.contributor.authorNiknejad, Amir
dc.contributor.authorRaczkowski, Lukasz
dc.contributor.authorReinders, Marcel
dc.contributor.authorRidder, Jeroen de
dc.contributor.authorSaliba, Antoine-Emmanuel
dc.contributor.authorSomarakis, Antonios
dc.contributor.authorStegle, Oliver
dc.contributor.authorTheis, Fabian J.
dc.contributor.authorYang, Huan
dc.contributor.authorZelikovsky, Alex
dc.contributor.authorMcHardy, Alice C.
dc.contributor.authorRaphael, Benjamin J.
dc.contributor.authorShah, Sohrab P.
dc.contributor.authorSchönhuth, Alexander
dc.date.accessioned2021-02-06T16:16:48Z
dc.date.available2021-02-06T16:16:48Z
dc.date.issued2020-02-07
dc.date.submitted2019-08-02
dc.identifier.others13059-020-1926-6
dc.identifier.other1926
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/317274
dc.description.abstractAbstract: The recent boom in microfluidics and combinatorial indexing strategies, combined with low sequencing costs, has empowered single-cell sequencing technology. Thousands—or even millions—of cells analyzed in a single experiment amount to a data revolution in single-cell biology and pose unique data science problems. Here, we outline eleven challenges that will be central to bringing this emerging field of single-cell data science forward. For each challenge, we highlight motivating research questions, review prior work, and formulate open problems. This compendium is for established researchers, newcomers, and students alike, highlighting interesting and rewarding problems for the coming years.
dc.languageen
dc.publisherBioMed Central
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectReview
dc.titleEleven grand challenges in single-cell data science
dc.typeArticle
dc.date.updated2021-02-06T16:16:48Z
prism.issueIdentifier1
prism.publicationNameGenome Biology
prism.volume21
dc.identifier.doi10.17863/CAM.64387
dcterms.dateAccepted2020-01-02
rioxxterms.versionofrecord10.1186/s13059-020-1926-6
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidRobinson, Mark D. [0000-0002-3048-5518]
dc.identifier.eissn1474-760X


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)