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dc.contributor.authorEloranta, Aino-Maija
dc.contributor.authorSallinen, Taisa
dc.contributor.authorViitasalo, Anna
dc.contributor.authorLintu, Niina
dc.contributor.authorVäistö, Juuso
dc.contributor.authorJalkanen, Henna
dc.contributor.authorTompuri, Tuomo T.
dc.contributor.authorSoininen, Sonja
dc.contributor.authorHaapala, Eero A.
dc.contributor.authorKiiskinen, Sanna
dc.contributor.authorSchnurr, Theresia M.
dc.contributor.authorKilpeläinen, Tuomas O.
dc.contributor.authorMikkonen, Santtu
dc.contributor.authorSavonen, Kai
dc.contributor.authorAtalay, Mustafa
dc.contributor.authorBrage, Soren
dc.contributor.authorLaaksonen, David E.
dc.contributor.authorLindi, Virpi
dc.contributor.authorÅgren, Jyrki
dc.contributor.authorSchwab, Ursula
dc.contributor.authorJääskeläinen, Jarmo
dc.contributor.authorLakka, Timo A.
dc.date.accessioned2021-02-06T16:16:50Z
dc.date.available2021-02-06T16:16:50Z
dc.date.issued2020-05-04
dc.date.submitted2019-09-24
dc.identifier.issn1436-6207
dc.identifier.others00394-020-02260-x
dc.identifier.other2260
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/317275
dc.descriptionFunder: Opetus- ja Kulttuuriministeriö; doi: http://dx.doi.org/10.13039/501100003126
dc.descriptionFunder: Sosiaali- ja Terveysministeriö; doi: http://dx.doi.org/10.13039/501100008487
dc.description.abstractAbstract: Purpose: We studied the effects of a physical activity and dietary intervention on plasma lipids in a general population of children. We also investigated how lifestyle changes contributed to the intervention effects. Methods: We carried out a 2-year controlled, non-randomized lifestyle intervention study among 504 mainly prepubertal children aged 6–9 years at baseline. We assigned 306 children to the intervention group and 198 children to the control group. We assessed plasma concentrations of total, LDL, HDL, and VLDL cholesterol, triglycerides, HDL triglycerides, and VLDL triglycerides. We evaluated the consumption of foods using 4-day food records and physical activity using a movement and heart rate sensor. We analyzed data using linear mixed-effect models adjusted for age at baseline, sex, and pubertal stage at both time points. Furthermore, specific lifestyle variables were entered in these models. Results: Plasma LDL cholesterol decreased in the intervention group but did not change in the control group ( − 0.05 vs. 0.00 mmol/L, regression coefficient (β) = − 0.0385, p = 0.040 for group*time interaction). This effect was mainly explained by the changes in the consumption of high-fat vegetable oil-based spreads (β = − 0.0203, + 47% change in β) and butter-based spreads (β = − 0.0294, + 30% change in β), moderate-to-vigorous physical activity (β = − 0.0268, + 30% change in β), light physical activity (β = − 0.0274, + 29% change in β) and sedentary time (β = − 0.0270, + 30% change in β). The intervention had no effect on other plasma lipids. Conclusion: Lifestyle intervention resulted a small decrease in plasma LDL cholesterol concentration in children. The effect was explained by changes in quality and quantity of dietary fat and physical activity. Clinical Trial Registry Number: NCT01803776, ClinicalTrials.gov
dc.languageen
dc.publisherSpringer Berlin Heidelberg
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectOriginal Contribution
dc.subjectIntervention
dc.subjectChildren
dc.subjectLipoproteins
dc.subjectLDL cholesterol
dc.subjectPhysical activity
dc.subjectDiet
dc.titleThe effects of a 2-year physical activity and dietary intervention on plasma lipid concentrations in children: the PANIC Study
dc.typeArticle
dc.date.updated2021-02-06T16:16:50Z
prism.endingPage434
prism.issueIdentifier1
prism.publicationNameEuropean Journal of Nutrition
prism.startingPage425
prism.volume60
dc.identifier.doi10.17863/CAM.64388
dcterms.dateAccepted2020-04-24
rioxxterms.versionofrecord10.1007/s00394-020-02260-x
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidSallinen, Taisa [0000-0003-2769-6338]
dc.identifier.eissn1436-6215


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)