The role of noncoding RNAs in epithelial cancer
Publication Date
2020-03-12Journal Title
Cell Death Discovery
Publisher
Nature Publishing Group UK
Volume
6
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Agostini, M., Ganini, C., Candi, E., & Melino, G. (2020). The role of noncoding RNAs in epithelial cancer. Cell Death Discovery, 6 (1) https://doi.org/10.1038/s41420-020-0247-6
Description
Funder: RCUK | Medical Research Council (MRC); doi: https://doi.org/10.13039/501100000265
Funder: Fondazione Luigi Maria Monti IDI-IRCCS (RC)
Abstract
Abstract: Regulatory noncoding RNAs (ncRNAs) are a class of RNAs transcribed by regions of the human genome that do not encode for proteins. The three main members of this class, named microRNA, long noncoding RNA, and circular RNA play a key role in the regulation of gene expression, eventually shaping critical cellular processes. Compelling experimental evidence shows that ncRNAs function either as tumor suppressors or oncogenes by participating in the regulation of one or several cancer hallmarks, including evading cell death, and their expression is frequently deregulated during cancer onset, progression, and dissemination. More recently, preclinical and clinical studies indicate that ncRNAs are potential biomarkers for monitoring cancer progression, relapse, and response to cancer therapy. Here, we will discuss the role of noncoding RNAs in regulating cancer cell death, focusing on those ncRNAs with a potential clinical relevance.
Keywords
Review Article, /631/337/384/2568, /631/337/384/331, review-article
Sponsorship
Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) (IG#20473, IG#22206)
Ministero della Salute (Ministry of Health, Italy) (#PGR00961)
Identifiers
s41420-020-0247-6, 247
External DOI: https://doi.org/10.1038/s41420-020-0247-6
This record's URL: https://www.repository.cam.ac.uk/handle/1810/317398
Rights
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/
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