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The role of noncoding RNAs in epithelial cancer

Published version
Peer-reviewed

Change log

Authors

Agostini, Massimiliano 
Candi, Eleonora 
Melino, Gerry 

Abstract

Abstract: Regulatory noncoding RNAs (ncRNAs) are a class of RNAs transcribed by regions of the human genome that do not encode for proteins. The three main members of this class, named microRNA, long noncoding RNA, and circular RNA play a key role in the regulation of gene expression, eventually shaping critical cellular processes. Compelling experimental evidence shows that ncRNAs function either as tumor suppressors or oncogenes by participating in the regulation of one or several cancer hallmarks, including evading cell death, and their expression is frequently deregulated during cancer onset, progression, and dissemination. More recently, preclinical and clinical studies indicate that ncRNAs are potential biomarkers for monitoring cancer progression, relapse, and response to cancer therapy. Here, we will discuss the role of noncoding RNAs in regulating cancer cell death, focusing on those ncRNAs with a potential clinical relevance.

Description

Funder: RCUK | Medical Research Council (MRC); doi: https://doi.org/10.13039/501100000265


Funder: Fondazione Luigi Maria Monti IDI-IRCCS (RC)

Keywords

Review Article, /631/337/384/2568, /631/337/384/331, review-article

Journal Title

Cell Death Discovery

Conference Name

Journal ISSN

2058-7716

Volume Title

6

Publisher

Nature Publishing Group UK
Sponsorship
Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) (IG#20473, IG#22206)
Ministero della Salute (Ministry of Health, Italy) (#PGR00961)