Nutritional and developmental programming effects of insulin.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Abstract
The discovery of insulin in 1921 was a major breakthrough in medicine and for therapy in patients with diabetes. The dramatic rise in the prevalence of overweight and obesity has been tightly linked to an increased prevalence of gestational diabetes mellitus (GDM), which poses major health concerns. Babies born to GDM mothers are more likely to develop obesity, type 2 diabetes and cardiovascular disease later in life. Evidence accumulated during the past two decades has revealed that high levels insulin, such as those observed during GDM, can have a widespread effect on the development and function of a variety of organs. This review summarises our current knowledge on the role of insulin in the placenta, cardiovascular system and brain during critical periods of development, as well as how it can contribute to lifelong metabolic regulation. We also discuss possible intervention strategies to ameliorate and hopefully reverse the developmental defects associated with obesity and GDM.
Description
Keywords
Journal Title
Conference Name
Journal ISSN
1365-2826
Volume Title
Publisher
Publisher DOI
Rights
Sponsorship
Wellcome Trust (106026/Z/14/Z)
British Heart Foundation (RG/17/12/33167)
MRC (MC_UU_00014/4)
Medical Research Council (MC_PC_12012)