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Nutritional and developmental programming effects of insulin.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Dearden, Laura 
Bouret, Sebastien G  ORCID logo  https://orcid.org/0000-0002-4174-9769
Ozanne, Susan E 

Abstract

The discovery of insulin in 1921 was a major breakthrough in medicine and for therapy in patients with diabetes. The dramatic rise in the prevalence of overweight and obesity has been tightly linked to an increased prevalence of gestational diabetes mellitus (GDM), which poses major health concerns. Babies born to GDM mothers are more likely to develop obesity, type 2 diabetes and cardiovascular disease later in life. Evidence accumulated during the past two decades has revealed that high levels insulin, such as those observed during GDM, can have a widespread effect on the development and function of a variety of organs. This review summarises our current knowledge on the role of insulin in the placenta, cardiovascular system and brain during critical periods of development, as well as how it can contribute to lifelong metabolic regulation. We also discuss possible intervention strategies to ameliorate and hopefully reverse the developmental defects associated with obesity and GDM.

Description

Keywords

developmental programming, diabetes, hormones, hypothalamus, obesity

Journal Title

J Neuroendocrinol

Conference Name

Journal ISSN

0953-8194
1365-2826

Volume Title

33

Publisher

Wiley

Rights

All rights reserved
Sponsorship
Medical Research Council (MC_UU_12012/4)
Wellcome Trust (106026/Z/14/Z)
British Heart Foundation (RG/17/12/33167)
MRC (MC_UU_00014/4)
Medical Research Council (MC_PC_12012)