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dc.contributor.authorDearden, Laura
dc.contributor.authorBouret, Sebastien G
dc.contributor.authorOzanne, Susan
dc.date.accessioned2021-02-10T00:30:26Z
dc.date.available2021-02-10T00:30:26Z
dc.date.issued2021-01-13
dc.identifier.issn0953-8194
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/317429
dc.description.abstractThe discovery of insulin in 1921 was a major breakthrough in medicine and for therapy in patients with diabetes. The dramatic rise in the prevalence of overweight and obesity has been tightly linked to an increased prevalence of gestational diabetes mellitus (GDM), which poses major health concerns. Babies born to GDM mothers are more likely to develop obesity, type 2 diabetes and cardiovascular disease later in life. Evidence accumulated during the past two decades has revealed that high levels insulin, such as those observed during GDM, can have a widespread effect on the development and function of a variety of organs. This review summarises our current knowledge on the role of insulin in the placenta, cardiovascular system and brain during critical periods of development, as well as how it can contribute to lifelong metabolic regulation. We also discuss possible intervention strategies to ameliorate and hopefully reverse the developmental defects associated with obesity and GDM.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.rightsAll rights reserved
dc.titleNutritional and developmental programming effects of insulin.
dc.typeArticle
prism.issueIdentifier4
prism.publicationDate2021
prism.publicationNameJ Neuroendocrinol
prism.startingPagee12933
prism.volume33
dc.identifier.doi10.17863/CAM.64542
dcterms.dateAccepted2020-12-11
rioxxterms.versionofrecord10.1111/jne.12933
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-01-13
dc.contributor.orcidBouret, Sebastien G [0000-0002-4174-9769]
dc.contributor.orcidOzanne, Susan [0000-0001-8753-5144]
dc.identifier.eissn1365-2826
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12012/4)
pubs.funder-project-idWellcome Trust (106026/Z/14/Z)
pubs.funder-project-idBritish Heart Foundation (RG/17/12/33167)
pubs.funder-project-idMRC (MC_UU_00014/4)
cam.issuedOnline2021-01-13
cam.orpheus.successMon Feb 15 07:30:26 GMT 2021 - Embargo updated
rioxxterms.freetoread.startdate2022-01-13


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