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dc.contributor.authorMartin-Ruiz, Carmen
dc.contributor.authorHoffmann, Jedrzej
dc.contributor.authorShmeleva, Evgeniya
dc.contributor.authorZglinicki, Thomas von
dc.contributor.authorRichardson, Gavin
dc.contributor.authorDraganova, Lilia
dc.contributor.authorRedgrave, Rachael
dc.contributor.authorCollerton, Joanna
dc.contributor.authorArthur, Helen
dc.contributor.authorKeavney, Bernard
dc.contributor.authorSpyridopoulos, Ioakim
dc.date.accessioned2021-02-12T17:30:00Z
dc.date.available2021-02-12T17:30:00Z
dc.date.issued2020-01-21
dc.date.submitted2019-06-25
dc.identifier.others41514-019-0041-y
dc.identifier.other41
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/317553
dc.descriptionFunder: The author is supported by the British Heart Foundation
dc.descriptionFunder: British Heart Foundation PG/15/85/31744 and PG/18/25/33587, Newcastle Healthcare Charity, Medical Research Council (G0500997 to TK, CJ and TvZ, G0601333 to TvZ) and the NIHR Biomedical Research Centre in Ageing and Chronic Disease.
dc.descriptionFunder: BK holds a British Heart Foundation personal chair.
dc.description.abstractAbstract: Cytomegalovirus (CMV) seropositivity in adults has been linked to increased cardiovascular disease burden. Phenotypically, CMV infection leads to an inflated CD8 T-lymphocyte compartment. We employed a 8-colour flow cytometric protocol to analyse circulating T cells in 597 octogenarians from the same birth cohort together with NT-proBNP measurements and followed all participants over 7 years. We found that, independent of CMV serostatus, a high number of CD27−CD28+ CD8 EMRA T-lymphocytes (TEMRA) protected from all-cause death after adjusting for known risk factors, such as heart failure, frailty or cancer (Hazard ratio 0.66 for highest vs lowest tertile; confidence interval 0.51–0.86). In addition, CD27−CD28+ CD8 EMRA T-lymphocytes protected from both, non-cardiovascular (hazard ratio 0.59) and cardiovascular death (hazard ratio 0.65). In aged mice treated with the senolytic navitoclax, in which we have previously shown a rejuvenated cardiac phenotype, CD8 effector memory cells are decreased, further indicating that alterations in T cell subpopulations are associated with cardiovascular ageing. Future studies are required to show whether targeting immunosenescence will lead to enhanced life- or healthspan.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectBrief Communication
dc.subject/692/53
dc.subject/631/80/509
dc.subjectbrief-communication
dc.titleCMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians
dc.typeArticle
dc.date.updated2021-02-12T17:29:59Z
prism.issueIdentifier1
prism.publicationNamenpj Aging and Mechanisms of Disease
prism.volume6
dc.identifier.doi10.17863/CAM.64666
dcterms.dateAccepted2019-12-19
rioxxterms.versionofrecord10.1038/s41514-019-0041-y
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidShmeleva, Evgeniya [0000-0002-7654-2960]
dc.contributor.orcidRichardson, Gavin [0000-0002-2310-9987]
dc.contributor.orcidDraganova, Lilia [0000-0003-1371-104X]
dc.contributor.orcidKeavney, Bernard [0000-0001-9573-0812]
dc.contributor.orcidSpyridopoulos, Ioakim [0000-0002-2750-2444]
dc.identifier.eissn2056-3973


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)