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dc.contributor.authorKos, Zuzana
dc.contributor.authorRoblin, Elvire
dc.contributor.authorKim, Rim S.
dc.contributor.authorMichiels, Stefan
dc.contributor.authorGallas, Brandon D.
dc.contributor.authorChen, Weijie
dc.contributor.authorvan de Vijver, Koen K.
dc.contributor.authorGoel, Shom
dc.contributor.authorAdams, Sylvia
dc.contributor.authorDemaria, Sandra
dc.contributor.authorViale, Giuseppe
dc.contributor.authorNielsen, Torsten O.
dc.contributor.authorBadve, Sunil S.
dc.contributor.authorSymmans, W. Fraser
dc.contributor.authorSotiriou, Christos
dc.contributor.authorRimm, David L.
dc.contributor.authorHewitt, Stephen
dc.contributor.authorDenkert, Carsten
dc.contributor.authorLoibl, Sibylle
dc.contributor.authorLuen, Stephen J.
dc.contributor.authorBartlett, John M. S.
dc.contributor.authorSavas, Peter
dc.contributor.authorPruneri, Giancarlo
dc.contributor.authorDillon, Deborah A.
dc.contributor.authorCheang, Maggie Chon U.
dc.contributor.authorTutt, Andrew
dc.contributor.authorHall, Jacqueline A.
dc.contributor.authorKok, Marleen
dc.contributor.authorHorlings, Hugo M.
dc.contributor.authorMadabhushi, Anant
dc.contributor.authorvan der Laak, Jeroen
dc.contributor.authorCiompi, Francesco
dc.contributor.authorLaenkholm, Anne-Vibeke
dc.contributor.authorBellolio, Enrique
dc.contributor.authorGruosso, Tina
dc.contributor.authorFox, Stephen B.
dc.contributor.authorAraya, Juan Carlos
dc.contributor.authorFloris, Giuseppe
dc.contributor.authorHudeček, Jan
dc.contributor.authorVoorwerk, Leonie
dc.contributor.authorBeck, Andrew H.
dc.contributor.authorKerner, Jen
dc.contributor.authorLarsimont, Denis
dc.contributor.authorDeclercq, Sabine
dc.contributor.authorVan den Eynden, Gert
dc.contributor.authorPusztai, Lajos
dc.contributor.authorEhinger, Anna
dc.contributor.authorYang, Wentao
dc.contributor.authorAbdulJabbar, Khalid
dc.contributor.authorYuan, Yinyin
dc.contributor.authorSingh, Rajendra
dc.contributor.authorHiley, Crispin
dc.contributor.authorBakir, Maise al
dc.contributor.authorLazar, Alexander J.
dc.contributor.authorNaber, Stephen
dc.contributor.authorWienert, Stephan
dc.contributor.authorCastillo, Miluska
dc.contributor.authorCurigliano, Giuseppe
dc.contributor.authorDieci, Maria-Vittoria
dc.contributor.authorAndré, Fabrice
dc.contributor.authorSwanton, Charles
dc.contributor.authorReis-Filho, Jorge
dc.contributor.authorSparano, Joseph
dc.contributor.authorBalslev, Eva
dc.contributor.authorChen, I-Chun
dc.contributor.authorStovgaard, Elisabeth Ida Specht
dc.contributor.authorPogue-Geile, Katherine
dc.contributor.authorBlenman, Kim R. M.
dc.contributor.authorPenault-Llorca, Frédérique
dc.contributor.authorSchnitt, Stuart
dc.contributor.authorLakhani, Sunil R.
dc.contributor.authorVincent-Salomon, Anne
dc.contributor.authorRojo, Federico
dc.contributor.authorBraybrooke, Jeremy P.
dc.contributor.authorHanna, Matthew G.
dc.contributor.authorSoler-Monsó, M. Teresa
dc.contributor.authorBethmann, Daniel
dc.contributor.authorCastaneda, Carlos A.
dc.contributor.authorWillard-Gallo, Karen
dc.contributor.authorSharma, Ashish
dc.contributor.authorLien, Huang-Chun
dc.contributor.authorFineberg, Susan
dc.contributor.authorThagaard, Jeppe
dc.contributor.authorComerma, Laura
dc.contributor.authorGonzalez-Ericsson, Paula
dc.contributor.authorBrogi, Edi
dc.contributor.authorLoi, Sherene
dc.contributor.authorSaltz, Joel
dc.contributor.authorKlaushen, Frederick
dc.contributor.authorCooper, Lee
dc.contributor.authorAmgad, Mohamed
dc.contributor.authorMoore, David A.
dc.contributor.authorSalgado, Roberto
dc.contributor.authorHyytiäinen, Aini
dc.contributor.authorHida, Akira I.
dc.contributor.authorThompson, Alastair
dc.contributor.authorLefevre, Alex
dc.contributor.authorGown, Allen
dc.contributor.authorLo, Amy
dc.contributor.authorSapino, Anna
dc.contributor.authorMoreira, Andre M.
dc.contributor.authorRichardson, Andrea
dc.contributor.authorVingiani, Andrea
dc.contributor.authorBellizzi, Andrew M.
dc.contributor.authorGuerrero, Angel
dc.contributor.authorGrigoriadis, Anita
dc.contributor.authorGarrido-Castro, Ana C.
dc.contributor.authorCimino-Mathews, Ashley
dc.contributor.authorSrinivasan, Ashok
dc.contributor.authorAcs, Balazs
dc.contributor.authorSingh, Baljit
dc.contributor.authorCalhoun, Benjamin
dc.contributor.authorHaibe-Kans, Benjamin
dc.contributor.authorSolomon, Benjamin
dc.contributor.authorThapa, Bibhusal
dc.contributor.authorNelson, Brad H.
dc.contributor.authorBallesteroes-Merino, Carmen
dc.contributor.authorCriscitiello, Carmen
dc.contributor.authorBoeckx, Carolien
dc.contributor.authorColpaert, Cecile
dc.contributor.authorQuinn, Cecily
dc.contributor.authorChennubhotla, Chakra S.
dc.contributor.authorSolinas, Cinzia
dc.contributor.authorDrubay, Damien
dc.contributor.authorSabanathan, Dhanusha
dc.contributor.authorPeeters, Dieter
dc.contributor.authorZardavas, Dimitrios
dc.contributor.authorHöflmayer, Doris
dc.contributor.authorJohnson, Douglas B.
dc.contributor.authorThompson, E. Aubrey
dc.contributor.authorPerez, Edith
dc.contributor.authorElGabry, Ehab A.
dc.contributor.authorBlackley, Elizabeth F.
dc.contributor.authorReisenbichler, Emily
dc.contributor.authorChmielik, Ewa
dc.contributor.authorGaire, Fabien
dc.contributor.authorLu, Fang-I
dc.contributor.authorAzmoudeh-Ardalan, Farid
dc.contributor.authorPeale, Franklin
dc.contributor.authorHirsch, Fred R.
dc.contributor.authorAcosta-Haab, Gabriela
dc.contributor.authorFarshid, Gelareh
dc.contributor.authorBroeckx, Glenn
dc.contributor.authorKoeppen, Harmut
dc.contributor.authorHaynes, Harry R.
dc.contributor.authorMcArthur, Heather
dc.contributor.authorJoensuu, Heikki
dc.contributor.authorOlofsson, Helena
dc.contributor.authorCree, Ian
dc.contributor.authorNederlof, Iris
dc.contributor.authorFrahm, Isabel
dc.contributor.authorBrcic, Iva
dc.contributor.authorChan, Jack
dc.contributor.authorZiai, James
dc.contributor.authorBrock, Jane
dc.contributor.authorWeseling, Jelle
dc.contributor.authorGiltnane, Jennifer
dc.contributor.authorLemonnier, Jerome
dc.contributor.authorZha, Jiping
dc.contributor.authorRibeiro, Joana
dc.contributor.authorLennerz, Jochen K.
dc.contributor.authorCarter, Jodi M.
dc.contributor.authorHartman, Johan
dc.contributor.authorHainfellner, Johannes
dc.contributor.authorLe Quesne, John
dc.contributor.authorJuco, Jonathan W.
dc.contributor.authorvan den Berg, Jose
dc.contributor.authorSanchez, Joselyn
dc.contributor.authorCucherousset, Joël
dc.contributor.authorAdam, Julien
dc.contributor.authorBalko, Justin M.
dc.contributor.authorSaeger, Kai
dc.contributor.authorSiziopikou, Kalliopi
dc.contributor.authorSikorska, Karolina
dc.contributor.authorWeber, Karsten
dc.contributor.authorSteele, Keith E.
dc.contributor.authorEmancipator, Kenneth
dc.contributor.authorEl Bairi, Khalid
dc.contributor.authorAllison, Kimberly H.
dc.contributor.authorKorski, Konstanty
dc.contributor.authorBuisseret, Laurence
dc.contributor.authorShi, Leming
dc.contributor.authorKooreman, Loes F. S.
dc.contributor.authorMolinero, Luciana
dc.contributor.authorEstrada, M. Valeria
dc.contributor.authorVan Seijen, Maartje
dc.contributor.authorLacroix-Triki, Magali
dc.contributor.authorSebastian, Manu M.
dc.contributor.authorBalancin, Marcelo L.
dc.contributor.authorMathieu, Marie-Christine
dc.contributor.authorvan de Vijver, Mark
dc.contributor.authorRebelatto, Marlon C.
dc.contributor.authorPiccart, Martine
dc.contributor.authorGoetz, Matthew P.
dc.contributor.authorPreusser, Matthias
dc.contributor.authorKhojasteh, Mehrnoush
dc.contributor.authorSanders, Melinda E.
dc.contributor.authorRegan, Meredith M.
dc.contributor.authorBarnes, Michael
dc.contributor.authorChristie, Michael
dc.contributor.authorMisialek, Michael
dc.contributor.authorIgnatiadis, Michail
dc.contributor.authorde Maaker, Michiel
dc.contributor.authorVan Bockstal, Mieke
dc.contributor.authorHarbeck, Nadia
dc.contributor.authorTung, Nadine
dc.contributor.authorLaudus, Nele
dc.contributor.authorSirtaine, Nicolas
dc.contributor.authorBurchardi, Nicole
dc.contributor.authorTernes, Nils
dc.contributor.authorRadosevic-Robin, Nina
dc.contributor.authorGluz, Oleg
dc.contributor.authorGrimm, Oliver
dc.contributor.authorNuciforo, Paolo
dc.contributor.authorJank, Paul
dc.contributor.authorKirtani, Pawan
dc.contributor.authorWatson, Peter H.
dc.contributor.authorJelinic, Peter
dc.contributor.authorFrancis, Prudence A.
dc.contributor.authorRussell, Prudence A.
dc.contributor.authorPierce, Robert H.
dc.contributor.authorHills, Robert
dc.contributor.authorLeon-Ferre, Roberto
dc.contributor.authorde Wind, Roland
dc.contributor.authorShui, Ruohong
dc.contributor.authorLeung, Samuel
dc.contributor.authorTabbarah, Sami
dc.contributor.authorSouza, Sandra C.
dc.contributor.authorO’Toole, Sandra
dc.contributor.authorSwain, Sandra
dc.contributor.authorDudgeon, Sarah
dc.contributor.authorWillis, Scooter
dc.contributor.authorEly, Scott
dc.contributor.authorBedri, Shahinaz
dc.contributor.authorIrshad, Sheeba
dc.contributor.authorLiu, Shiwei
dc.contributor.authorHendry, Shona
dc.contributor.authorBianchi, Simonetta
dc.contributor.authorBragança, Sofia
dc.contributor.authorPaik, Soonmyung
dc.contributor.authorLuz, Sua
dc.contributor.authorGevaert, Thomas
dc.contributor.authord’Alfons, Timothy
dc.contributor.authorJohn, Tom
dc.contributor.authorSugie, Tomohagu
dc.contributor.authorKurkure, Uday
dc.contributor.authorBossuyt, Veerle
dc.contributor.authorManem, Venkata
dc.contributor.authorCámaea, Vincente Peg
dc.contributor.authorTong, Weida
dc.contributor.authorTran, William T.
dc.contributor.authorWang, Yihong
dc.contributor.authorAllory, Yves
dc.contributor.authorHusain, Zaheed
dc.contributor.authorBago-Horvath, Zsuzsanna
dc.date.accessioned2021-02-12T17:30:31Z
dc.date.available2021-02-12T17:30:31Z
dc.date.issued2020-05-12
dc.date.submitted2019-07-21
dc.identifier.others41523-020-0156-0
dc.identifier.other156
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/317562
dc.description.abstractAbstract: Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the clinical and research communities. We evaluated sources of variability in sTIL assessment by pathologists in three previous sTIL ring studies. We identify common challenges and evaluate impact of discrepancies on outcome estimates in early TNBC using a newly-developed prognostic tool. Discordant sTIL assessment is driven by heterogeneity in lymphocyte distribution. Additional factors include: technical slide-related issues; scoring outside the tumor boundary; tumors with minimal assessable stroma; including lymphocytes associated with other structures; and including other inflammatory cells. Small variations in sTIL assessment modestly alter risk estimation in early TNBC but have the potential to affect treatment selection if cutpoints are employed. Scoring and averaging multiple areas, as well as use of reference images, improve consistency of sTIL evaluation. Moreover, to assist in avoiding the pitfalls identified in this analysis, we developed an educational resource available at www.tilsinbreastcancer.org/pitfalls.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/67/580/1884
dc.subject/692/53/2422
dc.subjectarticle
dc.titlePitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer
dc.typeArticle
dc.date.updated2021-02-12T17:30:30Z
prism.issueIdentifier1
prism.publicationNamenpj Breast Cancer
prism.volume6
dc.identifier.doi10.17863/CAM.64675
dcterms.dateAccepted2020-03-02
rioxxterms.versionofrecord10.1038/s41523-020-0156-0
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidGallas, Brandon D. [0000-0001-7332-1620]
dc.contributor.orcidvan de Vijver, Koen K. [0000-0002-2026-9790]
dc.contributor.orcidDemaria, Sandra [0000-0003-4426-0499]
dc.contributor.orcidBadve, Sunil S. [0000-0001-8861-9980]
dc.contributor.orcidSymmans, W. Fraser [0000-0002-1526-184X]
dc.contributor.orcidRimm, David L. [0000-0001-5820-4397]
dc.contributor.orcidSavas, Peter [0000-0001-5999-428X]
dc.contributor.orcidHall, Jacqueline A. [0000-0003-0708-1360]
dc.contributor.orcidHorlings, Hugo M. [0000-0003-4782-8828]
dc.contributor.orcidvan der Laak, Jeroen [0000-0001-7982-0754]
dc.contributor.orcidBellolio, Enrique [0000-0003-0079-5264]
dc.contributor.orcidAraya, Juan Carlos [0000-0003-3501-8203]
dc.contributor.orcidFloris, Giuseppe [0000-0003-2391-5425]
dc.contributor.orcidHudeček, Jan [0000-0003-1071-5686]
dc.contributor.orcidEhinger, Anna [0000-0001-9225-7396]
dc.contributor.orcidLazar, Alexander J. [0000-0002-6395-4499]
dc.contributor.orcidCastillo, Miluska [0000-0002-0111-3176]
dc.contributor.orcidCurigliano, Giuseppe [0000-0003-1781-2518]
dc.contributor.orcidSparano, Joseph [0000-0002-9031-2010]
dc.contributor.orcidBraybrooke, Jeremy P. [0000-0003-1943-7360]
dc.contributor.orcidHanna, Matthew G. [0000-0002-7536-1746]
dc.contributor.orcidWillard-Gallo, Karen [0000-0002-1150-1295]
dc.contributor.orcidSharma, Ashish [0000-0002-1011-6504]
dc.contributor.orcidComerma, Laura [0000-0002-0249-4636]
dc.contributor.orcidGonzalez-Ericsson, Paula [0000-0002-6292-6963]
dc.contributor.orcidLoi, Sherene [0000-0001-6137-9171]
dc.contributor.orcidCooper, Lee [0000-0002-3504-4965]
dc.identifier.eissn2374-4677
pubs.funder-project-idBreast Cancer Research Foundation (BCRF) (17-194)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)