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dc.contributor.authorAmgad, Mohamed
dc.contributor.authorStovgaard, Elisabeth Specht
dc.contributor.authorBalslev, Eva
dc.contributor.authorThagaard, Jeppe
dc.contributor.authorChen, Weijie
dc.contributor.authorDudgeon, Sarah
dc.contributor.authorSharma, Ashish
dc.contributor.authorKerner, Jennifer K.
dc.contributor.authorDenkert, Carsten
dc.contributor.authorYuan, Yinyin
dc.contributor.authorAbdulJabbar, Khalid
dc.contributor.authorWienert, Stephan
dc.contributor.authorSavas, Peter
dc.contributor.authorVoorwerk, Leonie
dc.contributor.authorBeck, Andrew H.
dc.contributor.authorMadabhushi, Anant
dc.contributor.authorHartman, Johan
dc.contributor.authorSebastian, Manu M.
dc.contributor.authorHorlings, Hugo M.
dc.contributor.authorHudeček, Jan
dc.contributor.authorCiompi, Francesco
dc.contributor.authorMoore, David A.
dc.contributor.authorSingh, Rajendra
dc.contributor.authorRoblin, Elvire
dc.contributor.authorBalancin, Marcelo Luiz
dc.contributor.authorMathieu, Marie-Christine
dc.contributor.authorLennerz, Jochen K.
dc.contributor.authorKirtani, Pawan
dc.contributor.authorChen, I-Chun
dc.contributor.authorBraybrooke, Jeremy P.
dc.contributor.authorPruneri, Giancarlo
dc.contributor.authorDemaria, Sandra
dc.contributor.authorAdams, Sylvia
dc.contributor.authorSchnitt, Stuart J.
dc.contributor.authorLakhani, Sunil R.
dc.contributor.authorRojo, Federico
dc.contributor.authorComerma, Laura
dc.contributor.authorBadve, Sunil S.
dc.contributor.authorKhojasteh, Mehrnoush
dc.contributor.authorSymmans, W. Fraser
dc.contributor.authorSotiriou, Christos
dc.contributor.authorGonzalez-Ericsson, Paula
dc.contributor.authorPogue-Geile, Katherine L.
dc.contributor.authorKim, Rim S.
dc.contributor.authorRimm, David L.
dc.contributor.authorViale, Giuseppe
dc.contributor.authorHewitt, Stephen M.
dc.contributor.authorBartlett, John M. S.
dc.contributor.authorPenault-Llorca, Frédérique
dc.contributor.authorGoel, Shom
dc.contributor.authorLien, Huang-Chun
dc.contributor.authorLoibl, Sibylle
dc.contributor.authorKos, Zuzana
dc.contributor.authorLoi, Sherene
dc.contributor.authorHanna, Matthew G.
dc.contributor.authorMichiels, Stefan
dc.contributor.authorKok, Marleen
dc.contributor.authorNielsen, Torsten O.
dc.contributor.authorLazar, Alexander J.
dc.contributor.authorBago-Horvath, Zsuzsanna
dc.contributor.authorKooreman, Loes F. S.
dc.contributor.authorvan der Laak, Jeroen A. W. M.
dc.contributor.authorSaltz, Joel
dc.contributor.authorGallas, Brandon D.
dc.contributor.authorKurkure, Uday
dc.contributor.authorBarnes, Michael
dc.contributor.authorSalgado, Roberto
dc.contributor.authorCooper, Lee A. D.
dc.contributor.authorHyytiäinen, Aini
dc.contributor.authorHida, Akira I.
dc.contributor.authorThompson, Alastair
dc.contributor.authorLefevre, Alex
dc.contributor.authorGown, Allen
dc.contributor.authorLo, Amy
dc.contributor.authorSapino, Anna
dc.contributor.authorMoreira, Andre
dc.contributor.authorRichardson, Andrea
dc.contributor.authorVingiani, Andrea
dc.contributor.authorBellizzi, Andrew M.
dc.contributor.authorTutt, Andrew
dc.contributor.authorGuerrero-Zotano, Angel
dc.contributor.authorGrigoriadis, Anita
dc.contributor.authorEhinger, Anna
dc.contributor.authorGarrido-Castro, Anna C.
dc.contributor.authorVincent-Salomon, Anne
dc.contributor.authorLaenkholm, Anne-Vibeke
dc.contributor.authorCimino-Mathews, Ashley
dc.contributor.authorSrinivasan, Ashok
dc.contributor.authorAcs, Balazs
dc.contributor.authorSingh, Baljit
dc.contributor.authorCalhoun, Benjamin
dc.contributor.authorHaibe-Kans, Benjamin
dc.contributor.authorSolomon, Benjamin
dc.contributor.authorThapa, Bibhusal
dc.contributor.authorNelson, Brad H.
dc.contributor.authorCastaneda, Carlos
dc.contributor.authorBallesteroes-Merino, Carmen
dc.contributor.authorCriscitiello, Carmen
dc.contributor.authorBoeckx, Carolien
dc.contributor.authorColpaert, Cecile
dc.contributor.authorQuinn, Cecily
dc.contributor.authorChennubhotla, Chakra S.
dc.contributor.authorSwanton, Charles
dc.contributor.authorSolinas, Cinzia
dc.contributor.authorHiley, Crispin
dc.contributor.authorDrubay, Damien
dc.contributor.authorBethmann, Daniel
dc.contributor.authorDillon, Deborah A.
dc.contributor.authorLarsimont, Denis
dc.contributor.authorSabanathan, Dhanusha
dc.contributor.authorPeeters, Dieter
dc.contributor.authorZardavas, Dimitrios
dc.contributor.authorHöflmayer, Doris
dc.contributor.authorJohnson, Douglas B.
dc.contributor.authorThompson, E. Aubrey
dc.contributor.authorBrogi, Edi
dc.contributor.authorPerez, Edith
dc.contributor.authorElGabry, Ehab A.
dc.contributor.authorBlackley, Elizabeth F.
dc.contributor.authorReisenbichler, Emily
dc.contributor.authorBellolio, Enrique
dc.contributor.authorChmielik, Ewa
dc.contributor.authorGaire, Fabien
dc.contributor.authorAndre, Fabrice
dc.contributor.authorLu, Fang-I
dc.contributor.authorAzmoudeh-Ardalan, Farid
dc.contributor.authorGruosso, Forbius Tina
dc.contributor.authorPeale, Franklin
dc.contributor.authorHirsch, Fred R.
dc.contributor.authorKlaushen, Frederick
dc.contributor.authorAcosta-Haab, Gabriela
dc.contributor.authorFarshid, Gelareh
dc.contributor.authorvan den Eynden, Gert
dc.contributor.authorCurigliano, Giuseppe
dc.contributor.authorFloris, Giuseppe
dc.contributor.authorBroeckx, Glenn
dc.contributor.authorKoeppen, Harmut
dc.contributor.authorHaynes, Harry R.
dc.contributor.authorMcArthur, Heather
dc.contributor.authorJoensuu, Heikki
dc.contributor.authorOlofsson, Helena
dc.contributor.authorCree, Ian
dc.contributor.authorNederlof, Iris
dc.contributor.authorFrahm, Isabel
dc.contributor.authorBrcic, Iva
dc.contributor.authorChan, Jack
dc.contributor.authorHall, Jacqueline A.
dc.contributor.authorZiai, James
dc.contributor.authorBrock, Jane
dc.contributor.authorWesseling, Jelle
dc.contributor.authorGiltnane, Jennifer
dc.contributor.authorLemonnier, Jerome
dc.contributor.authorZha, Jiping
dc.contributor.authorM. Ribeiro, Joana
dc.contributor.authorCarter, Jodi M.
dc.contributor.authorHainfellner, Johannes
dc.contributor.authorQuesne, John Le
dc.contributor.authorJuco, Jonathan W.
dc.contributor.authorReis-Filho, Jorge
dc.contributor.authorvan den Berg, Jose
dc.contributor.authorSanchez, Joselyn
dc.contributor.authorSparano, Joseph
dc.contributor.authorCucherousset, Joël
dc.contributor.authorAraya, Juan Carlos
dc.contributor.authorAdam, Julien
dc.contributor.authorBalko, Justin M.
dc.contributor.authorSaeger, Kai
dc.contributor.authorSiziopikou, Kalliopi
dc.contributor.authorWillard-Gallo, Karen
dc.contributor.authorSikorska, Karolina
dc.contributor.authorWeber, Karsten
dc.contributor.authorSteele, Keith E.
dc.contributor.authorEmancipator, Kenneth
dc.contributor.authorEl Bairi, Khalid
dc.contributor.authorBlenman, Kim R. M.
dc.contributor.authorAllison, Kimberly H.
dc.contributor.authorvan de Vijver, Koen K.
dc.contributor.authorKorski, Konstanty
dc.contributor.authorPusztai, Lajos
dc.contributor.authorBuisseret, Laurence
dc.contributor.authorShi, Leming
dc.contributor.authorShi-wei, Liu
dc.contributor.authorMolinero, Luciana
dc.contributor.authorEstrada, M. Valeria
dc.contributor.authorvan Seijen, Maartje
dc.contributor.authorLacroix-Triki, Magali
dc.contributor.authorCheang, Maggie C. U.
dc.contributor.authorBakir, Maise al
dc.contributor.authorvan de Vijver, Marc
dc.contributor.authorDieci, Maria Vittoria
dc.contributor.authorRebelatto, Marlon C.
dc.contributor.authorPiccart, Martine
dc.contributor.authorGoetz, Matthew P.
dc.contributor.authorPreusser, Matthias
dc.contributor.authorSanders, Melinda E.
dc.contributor.authorRegan, Meredith M.
dc.contributor.authorChristie, Michael
dc.contributor.authorMisialek, Michael
dc.contributor.authorIgnatiadis, Michail
dc.contributor.authorde Maaker, Michiel
dc.contributor.authorvan Bockstal, Mieke
dc.contributor.authorCastillo, Miluska
dc.contributor.authorHarbeck, Nadia
dc.contributor.authorTung, Nadine
dc.contributor.authorLaudus, Nele
dc.contributor.authorSirtaine, Nicolas
dc.contributor.authorBurchardi, Nicole
dc.contributor.authorTernes, Nils
dc.contributor.authorRadosevic-Robin, Nina
dc.contributor.authorGluz, Oleg
dc.contributor.authorGrimm, Oliver
dc.contributor.authorNuciforo, Paolo
dc.contributor.authorJank, Paul
dc.contributor.authorJelinic, Petar
dc.contributor.authorWatson, Peter H.
dc.contributor.authorFrancis, Prudence A.
dc.contributor.authorRussell, Prudence A.
dc.contributor.authorPierce, Robert H.
dc.contributor.authorHills, Robert
dc.contributor.authorLeon-Ferre, Roberto
dc.contributor.authorde Wind, Roland
dc.contributor.authorShui, Ruohong
dc.contributor.authorDeclercq, Sabine
dc.contributor.authorLeung, Sam
dc.contributor.authorTabbarah, Sami
dc.contributor.authorSouza, Sandra C.
dc.contributor.authorO’Toole, Sandra
dc.contributor.authorSwain, Sandra
dc.contributor.authorWillis, Scooter
dc.contributor.authorEly, Scott
dc.contributor.authorKim, Seong- Rim
dc.contributor.authorBedri, Shahinaz
dc.contributor.authorIrshad, Sheeba
dc.contributor.authorLiu, Shi-Wei
dc.contributor.authorHendry, Shona
dc.contributor.authorBianchi, Simonetta
dc.contributor.authorBragança, Sofia
dc.contributor.authorPaik, Soonmyung
dc.contributor.authorFox, Stephen B.
dc.contributor.authorLuen, Stephen J.
dc.contributor.authorNaber, Stephen
dc.contributor.authorLuz, Sua
dc.contributor.authorFineberg, Susan
dc.contributor.authorSoler, Teresa
dc.contributor.authorGevaert, Thomas
dc.contributor.authord’Alfons, Timothy
dc.contributor.authorJohn, Tom
dc.contributor.authorSugie, Tomohagu
dc.contributor.authorBossuyt, Veerle
dc.contributor.authorManem, Venkata
dc.contributor.authorCámaea, Vincente Peg
dc.contributor.authorTong, Weida
dc.contributor.authorYang, Wentao
dc.contributor.authorTran, William T.
dc.contributor.authorWang, Yihong
dc.contributor.authorAllory, Yves
dc.contributor.authorHusain, Zaheed
dc.date.accessioned2021-02-12T17:31:11Z
dc.date.available2021-02-12T17:31:11Z
dc.date.issued2020-05-12
dc.date.submitted2019-07-15
dc.identifier.others41523-020-0154-2
dc.identifier.other154
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/317573
dc.descriptionFunder: U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
dc.descriptionFunder: National Center for Research Resources under award number 1 C06 RR12463-01, VA Merit Review Award IBX004121A from the United States Department of Veterans Affairs Biomedical Laboratory Research and Development Service, the DOD Prostate Cancer Idea Development Award (W81XWH-15-1-0558), the DOD Lung Cancer Investigator-Initiated Translational Research Award (W81XWH-18-1-0440), the DOD Peer Reviewed Cancer Research Program (W81XWH-16-1-0329), the Ohio Third Frontier Technology Validation Fund, the Wallace H. Coulter Foundation Program in the Department of Biomedical Engineering and the Clinical and Translational Science Award Program (CTSA) at Case Western Reserve University.
dc.descriptionFunder: Susan G Komen Foundation (CCR CCR18547966) and a Young Investigator Grant from the Breast Cancer Alliance.
dc.descriptionFunder: The Canadian Cancer Society
dc.descriptionFunder: Breast Cancer Research Foundation (BCRF), Grant No. 17-194
dc.description.abstractAbstract: Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral part of the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer, as well as many other solid tumors. This recognition has come about thanks to standardized visual reporting guidelines, which helped to reduce inter-reader variability. Now, there are ripe opportunities to employ computational methods that extract spatio-morphologic predictive features, enabling computer-aided diagnostics. We detail the benefits of computational TILs assessment, the readiness of TILs scoring for computational assessment, and outline considerations for overcoming key barriers to clinical translation in this arena. Specifically, we discuss: 1. ensuring computational workflows closely capture visual guidelines and standards; 2. challenges and thoughts standards for assessment of algorithms including training, preanalytical, analytical, and clinical validation; 3. perspectives on how to realize the potential of machine learning models and to overcome the perceptual and practical limits of visual scoring.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectReview Article
dc.subject/692/53/2422
dc.subject/631/67/580
dc.subject/631/67/1347
dc.subject/692/4028/67/1857
dc.subject/631/67/2321
dc.subjectreview-article
dc.titleReport on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group
dc.typeArticle
dc.date.updated2021-02-12T17:31:10Z
prism.issueIdentifier1
prism.publicationNamenpj Breast Cancer
prism.volume6
dc.identifier.doi10.17863/CAM.64686
dcterms.dateAccepted2020-02-18
rioxxterms.versionofrecord10.1038/s41523-020-0154-2
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidAmgad, Mohamed [0000-0001-7599-6162]
dc.contributor.orcidSharma, Ashish [0000-0002-1011-6504]
dc.contributor.orcidSavas, Peter [0000-0001-5999-428X]
dc.contributor.orcidHudeček, Jan [0000-0003-1071-5686]
dc.contributor.orcidBraybrooke, Jeremy P. [0000-0003-1943-7360]
dc.contributor.orcidDemaria, Sandra [0000-0003-4426-0499]
dc.contributor.orcidComerma, Laura [0000-0002-0249-4636]
dc.contributor.orcidBadve, Sunil S. [0000-0001-8861-9980]
dc.contributor.orcidSymmans, W. Fraser [0000-0002-1526-184X]
dc.contributor.orcidGonzalez-Ericsson, Paula [0000-0002-6292-6963]
dc.contributor.orcidRimm, David L. [0000-0001-5820-4397]
dc.contributor.orcidLoi, Sherene [0000-0001-6137-9171]
dc.contributor.orcidHanna, Matthew G. [0000-0002-7536-1746]
dc.contributor.orcidLazar, Alexander J. [0000-0002-6395-4499]
dc.contributor.orcidBago-Horvath, Zsuzsanna [0000-0002-8555-7806]
dc.contributor.orcidvan der Laak, Jeroen A. W. M. [0000-0001-7982-0754]
dc.contributor.orcidGallas, Brandon D. [0000-0001-7332-1620]
dc.contributor.orcidKurkure, Uday [0000-0002-8273-7334]
dc.contributor.orcidCooper, Lee A. D. [0000-0002-3504-4965]
dc.identifier.eissn2374-4677
pubs.funder-project-idU.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) (1UG3CA225021, 1U24CA215109, Leidos 14X138, 1U24CA199374-01, R01CA202752-01A1, R01CA208236-01A1, R01 CA216579-01A1, R01 CA220581-01A1, 1U01 CA239055-01, P30 CA16672, UG3CA225021, U24CA215109)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)