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dc.contributor.authorWu, Yeda
dc.contributor.authorMurray, Graham K.
dc.contributor.authorByrne, Enda M.
dc.contributor.authorSidorenko, Julia
dc.contributor.authorVisscher, Peter M.
dc.contributor.authorWray, Naomi R.
dc.date.accessioned2021-02-19T16:18:24Z
dc.date.available2021-02-19T16:18:24Z
dc.date.issued2021-02-19
dc.date.submitted2020-06-15
dc.identifier.others41467-021-21280-7
dc.identifier.other21280
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/317902
dc.description.abstractAbstract: Genetic factors are recognized to contribute to peptic ulcer disease (PUD) and other gastrointestinal diseases, such as gastro-oesophageal reflux disease (GORD), irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Here, genome-wide association study (GWAS) analyses based on 456,327 UK Biobank (UKB) individuals identify 8 independent and significant loci for PUD at, or near, genes MUC1, MUC6, FUT2, PSCA, ABO, CDX2, GAST and CCKBR. There are previously established roles in susceptibility to Helicobacter pylori infection, response to counteract infection-related damage, gastric acid secretion or gastrointestinal motility for these genes. Only two associations have been previously reported for duodenal ulcer, here replicated trans-ancestrally. The results highlight the role of host genetic susceptibility to infection. Post-GWAS analyses for PUD, GORD, IBS and IBD add insights into relationships between these gastrointestinal diseases and their relationships with depression, a commonly comorbid disorder.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/208/205/2138
dc.subject/692/4020/1503/1502/2071
dc.subject/692/4020/1503/1476/196
dc.subject/692/4020/1503/1828/1722
dc.subject/45
dc.subject/45/43
dc.subject/38
dc.subject/38/91
dc.subjectarticle
dc.titleGWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression
dc.typeArticle
dc.date.updated2021-02-19T16:18:23Z
prism.issueIdentifier1
prism.publicationNameNature Communications
prism.volume12
dc.identifier.doi10.17863/CAM.65018
dcterms.dateAccepted2021-01-06
rioxxterms.versionofrecord10.1038/s41467-021-21280-7
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidWu, Yeda [0000-0002-5977-1526]
dc.contributor.orcidMurray, Graham K. [0000-0001-8296-1742]
dc.contributor.orcidSidorenko, Julia [0000-0003-1494-6772]
dc.contributor.orcidVisscher, Peter M. [0000-0002-2143-8760]
dc.contributor.orcidWray, Naomi R. [0000-0001-7421-3357]
dc.identifier.eissn2041-1723
pubs.funder-project-idDepartment of Health | National Health and Medical Research Council (NHMRC) (1078901, 1078037)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)