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dc.contributor.authorIrie, Naokoen
dc.contributor.authorTang, Walfreden
dc.contributor.authorAzim Surani, Men
dc.date.accessioned2021-02-20T00:30:09Z
dc.date.available2021-02-20T00:30:09Z
dc.date.issued2014-01en
dc.identifier.issn1445-5781
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/317906
dc.description.abstractGerm cells are unique cell types that generate a totipotent zygote upon fertilization, giving rise to the next generation in mammals and many other multicellular organisms. How germ cells acquire this ability has been of considerable interest. In mammals, primordial germ cells (PGCs), the precursors of sperm and oocytes, are specified around the time of gastrulation. PGCs are induced by signals from the surrounding extra-embryonic tissues to the equipotent epiblast cells that give rise to all cell types. Currently, the mechanism of PGC specification in mammals is best understood from studies in mice. Following implantation, the epiblast cells develop as an egg cylinder while the extra-embryonic ectoderm cells which are the source of important signals for PGC specification are located over the egg cylinder. However, in most cases, including humans, the epiblast cells develop as a planar disc, which alters the organization and the source of the signaling for cell fates. This, in turn, might have an effect on the precise mechanism of PGC specification in vivo as well as in vitro using pluripotent embryonic stem cells. Here, we discuss how the key early embryonic differences between rodents and other mammals may affect the establishment of the pluripotency network in vivo and in vitro, and consequently the basis for PGC specification, particularly from pluripotent embryonic stem cells in vitro.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleGerm cell specification and pluripotency in mammals: a perspective from early embryogenesis.en
dc.typeArticle
prism.endingPage215
prism.issueIdentifier4en
prism.publicationDate2014en
prism.publicationNameReproductive medicine and biologyen
prism.startingPage203
prism.volume13en
dc.identifier.doi10.17863/CAM.65022
dcterms.dateAccepted2014-05-19en
rioxxterms.versionofrecord10.1007/s12522-014-0184-2en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-01en
dc.contributor.orcidTang, Walfred [0000-0002-5803-1681]
dc.identifier.eissn1447-0578
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (092096/Z/10/Z)
pubs.funder-project-idWellcome Trust (097922/Z/11/B)
pubs.funder-project-idWellcome Trust (097922/B/11/Z)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International