Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse.
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Authors
Grigis, Antoine
Garavan, Hugh
Heinz, Andreas
Martinot, Jean-Luc
IMAGEN Consortium
Publication Date
2021-02Journal Title
Sci Adv
ISSN
2375-2548
Publisher
American Association for the Advancement of Science (AAAS)
Volume
7
Issue
6
Language
eng
Type
Article
This Version
VoR
Physical Medium
Electronic-Print
Metadata
Show full item recordCitation
Jia, T., Xie, C., Banaschewski, T., Barker, G. J., Bokde, A. L., Büchel, C., Quinlan, E. B., et al. (2021). Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse.. Sci Adv, 7 (6) https://doi.org/10.1126/sciadv.abd4074
Abstract
Prompted by recent evidence of neural circuitry in rodent models, functional magnetic resonance imaging and functional connectivity analyses were conducted for a large adolescent population at two ages, together with alcohol abuse measures, to characterize a neural network that may underlie the onset of alcoholism. A network centered on the medial orbitofrontal cortex (mOFC), as well as including the dorsal periaqueductal gray (dPAG), central nucleus of the amygdala, and nucleus accumbens, was identified, consistent with the rodent models, with evidence of both inhibitory and excitatory coregulation by the mOFC over the dPAG. Furthermore, significant relationships were detected between raised baseline excitatory coregulation in this network and impulsivity measures, supporting a role for negative urgency in alcohol dependence.
Keywords
IMAGEN Consortium
Identifiers
External DOI: https://doi.org/10.1126/sciadv.abd4074
This record's URL: https://www.repository.cam.ac.uk/handle/1810/318521
Rights
Attribution-NonCommercial 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc/4.0/
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