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dc.contributor.authorJia, Tianye
dc.contributor.authorXie, Chao
dc.contributor.authorBanaschewski, Tobias
dc.contributor.authorBarker, Gareth J
dc.contributor.authorBokde, Arun LW
dc.contributor.authorBüchel, Christian
dc.contributor.authorQuinlan, Erin Burke
dc.contributor.authorDesrivières, Sylvane
dc.contributor.authorFlor, Herta
dc.contributor.authorGrigis, Antoine
dc.contributor.authorGaravan, Hugh
dc.contributor.authorGowland, Penny
dc.contributor.authorHeinz, Andreas
dc.contributor.authorIttermann, Bernd
dc.contributor.authorMartinot, Jean-Luc
dc.contributor.authorMartinot, Marie-Laure Paillère
dc.contributor.authorNees, Frauke
dc.contributor.authorOrfanos, Dimitri Papadopoulos
dc.contributor.authorPoustka, Luise
dc.contributor.authorFröhner, Juliane H
dc.contributor.authorSmolka, Michael N
dc.contributor.authorWalter, Henrik
dc.contributor.authorWhelan, Robert
dc.contributor.authorSchumann, Gunter
dc.contributor.authorRobbins, Trevor W
dc.contributor.authorFeng, Jianfeng
dc.contributor.authorIMAGEN Consortium
dc.date.accessioned2021-03-09T00:30:38Z
dc.date.available2021-03-09T00:30:38Z
dc.date.issued2021-02
dc.identifier.issn2375-2548
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/318521
dc.description.abstractPrompted by recent evidence of neural circuitry in rodent models, functional magnetic resonance imaging and functional connectivity analyses were conducted for a large adolescent population at two ages, together with alcohol abuse measures, to characterize a neural network that may underlie the onset of alcoholism. A network centered on the medial orbitofrontal cortex (mOFC), as well as including the dorsal periaqueductal gray (dPAG), central nucleus of the amygdala, and nucleus accumbens, was identified, consistent with the rodent models, with evidence of both inhibitory and excitatory coregulation by the mOFC over the dPAG. Furthermore, significant relationships were detected between raised baseline excitatory coregulation in this network and impulsivity measures, supporting a role for negative urgency in alcohol dependence.
dc.format.mediumElectronic-Print
dc.languageeng
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectIMAGEN Consortium
dc.titleNeural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse.
dc.typeArticle
prism.issueIdentifier6
prism.publicationDate2021
prism.publicationNameSci Adv
prism.volume7
dc.identifier.doi10.17863/CAM.65635
dcterms.dateAccepted2020-12-16
rioxxterms.versionofrecord10.1126/sciadv.abd4074
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-02-03
dc.contributor.orcidJia, Tianye [0000-0001-5399-2953]
dc.contributor.orcidXie, Chao [0000-0002-9137-3835]
dc.contributor.orcidBanaschewski, Tobias [0000-0003-4595-1144]
dc.contributor.orcidBarker, Gareth J [0000-0002-5214-7421]
dc.contributor.orcidBokde, Arun LW [0000-0003-0114-4914]
dc.contributor.orcidBüchel, Christian [0000-0003-1965-906X]
dc.contributor.orcidQuinlan, Erin Burke [0000-0003-2927-1632]
dc.contributor.orcidDesrivières, Sylvane [0000-0002-9120-7060]
dc.contributor.orcidFlor, Herta [0000-0003-4809-5398]
dc.contributor.orcidGowland, Penny [0000-0002-4900-4817]
dc.contributor.orcidIttermann, Bernd [0000-0002-4087-471X]
dc.contributor.orcidMartinot, Marie-Laure Paillère [0000-0002-0452-2450]
dc.contributor.orcidNees, Frauke [0000-0002-7796-8234]
dc.contributor.orcidOrfanos, Dimitri Papadopoulos [0000-0002-1242-8990]
dc.contributor.orcidPoustka, Luise [0000-0002-7738-4394]
dc.contributor.orcidFröhner, Juliane H [0000-0002-8493-6396]
dc.contributor.orcidSmolka, Michael N [0000-0001-5398-5569]
dc.contributor.orcidWalter, Henrik [0000-0002-9403-6121]
dc.contributor.orcidWhelan, Robert [0000-0002-2790-7281]
dc.contributor.orcidSchumann, Gunter [0000-0002-7740-6469]
dc.contributor.orcidRobbins, Trevor W [0000-0003-0642-5977]
dc.contributor.orcidFeng, Jianfeng [0000-0002-9328-5732]
dc.identifier.eissn2375-2548
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-02-03


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International