PRDM9 sticks its zinc fingers into recombination hotspots and between species.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Sandovici, Ionel https://orcid.org/0000-0001-5674-4269
Sapienza, Carmen
Abstract
Meiotic recombination events typically cluster within narrow regions of the genome termed hotspots. A series of recent papers reveals that PRDM9, a C2H2-type zinc-finger protein with histone H3 lysine 4 methyltransferase activity, plays a major role in the specification of hotspots. The zinc fingers that contact DNA in a sequence-dependent manner evolve rapidly and are under positive selection, leading to differences in the location of recombination hotspots as well as hybrid sterility.
Description
Keywords
0604 Genetics, Biotechnology, Genetics, Human Genome, 1.1 Normal biological development and functioning
Journal Title
F1000 Biol Rep
Conference Name
Journal ISSN
1740-4118
1757-594X
1757-594X
Volume Title
2
Publisher
Faculty Opinions Ltd