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dc.contributor.authorHamilton, William L
dc.contributor.authorTonkin-Hill, Gerry
dc.contributor.authorSmith, Emily R
dc.contributor.authorAggarwal, Dinesh
dc.contributor.authorHouldcroft, Charlotte J
dc.contributor.authorWarne, Ben
dc.contributor.authorMeredith, Luke W
dc.contributor.authorHosmillo, Myra
dc.contributor.authorJahun, Aminu S
dc.contributor.authorCurran, Martin D
dc.contributor.authorParmar, Surendra
dc.contributor.authorCaller, Laura G
dc.contributor.authorCaddy, Sarah L
dc.contributor.authorKhokhar, Fahad A
dc.contributor.authorYakovleva, Anna
dc.contributor.authorHall, Grant
dc.contributor.authorFeltwell, Theresa
dc.contributor.authorPinckert, Malte L
dc.contributor.authorGeorgana, Iliana
dc.contributor.authorChaudhry, Yasmin
dc.contributor.authorBrown, Colin S
dc.contributor.authorGonçalves, Sonia
dc.contributor.authorAmato, Roberto
dc.contributor.authorHarrison, Ewan M
dc.contributor.authorBrown, Nicholas M
dc.contributor.authorBeale, Mathew A
dc.contributor.authorSpencer Chapman, Michael
dc.contributor.authorJackson, David K
dc.contributor.authorJohnston, Ian
dc.contributor.authorAlderton, Alex
dc.contributor.authorSillitoe, John
dc.contributor.authorLangford, Cordelia
dc.contributor.authorDougan, Gordon
dc.contributor.authorPeacock, Sharon J
dc.contributor.authorKwiatowski, Dominic P
dc.contributor.authorGoodfellow, Ian G
dc.contributor.authorTorok, M Estee
dc.contributor.authorCOVID-19 Genomics Consortium UK
dc.date.accessioned2021-03-27T05:09:00Z
dc.date.available2021-03-27T05:09:00Z
dc.date.issued2021-03-02
dc.date.submitted2020-11-04
dc.identifier.other64618
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/319294
dc.descriptionFunder: National Institute for Health Research; FundRef: http://dx.doi.org/10.13039/501100000272
dc.description.abstractCOVID-19 poses a major challenge to care homes, as SARS-CoV-2 is readily transmitted and causes disproportionately severe disease in older people. Here, 1167 residents from 337 care homes were identified from a dataset of 6600 COVID-19 cases from the East of England. Older age and being a care home resident were associated with increased mortality. SARS-CoV-2 genomes were available for 700 residents from 292 care homes. By integrating genomic and temporal data, 409 viral clusters within the 292 homes were identified, indicating two different patterns – outbreaks among care home residents and independent introductions with limited onward transmission. Approximately 70% of residents in the genomic analysis were admitted to hospital during the study, providing extensive opportunities for transmission between care homes and hospitals. Limiting viral transmission within care homes should be a key target for infection control to reduce COVID-19 mortality in this population.
dc.languageen
dc.publishereLife Sciences Publications, Ltd
dc.subjectResearch Article
dc.subjectEpidemiology and Global Health
dc.subjectGenetics and Genomics
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectgenomics
dc.subjectepidemiology
dc.subjectVirus
dc.titleGenomic epidemiology of COVID-19 in care homes in the east of England
dc.typeArticle
dc.date.updated2021-03-27T05:09:00Z
prism.publicationNameeLife
prism.volume10
dc.identifier.doi10.17863/CAM.66412
dcterms.dateAccepted2021-02-25
rioxxterms.versionofrecord10.7554/elife.64618
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: Wesolowski, Amy
datacite.contributor.supervisorsenior_editor: Davenport, Miles P
dc.contributor.orcidHamilton, William L [0000-0002-3330-353X]
dc.contributor.orcidTonkin-Hill, Gerry [0000-0003-4397-2224]
dc.contributor.orcidAggarwal, Dinesh [0000-0002-5938-8172]
dc.contributor.orcidHouldcroft, Charlotte J [0000-0002-1833-5285]
dc.contributor.orcidHosmillo, Myra [0000-0002-3514-7681]
dc.contributor.orcidJahun, Aminu S [0000-0002-4585-1701]
dc.contributor.orcidCaddy, Sarah L [0000-0002-9790-7420]
dc.contributor.orcidHall, Grant [0000-0003-3928-3979]
dc.contributor.orcidGeorgana, Iliana [0000-0002-8976-1177]
dc.contributor.orcidBrown, Nicholas M [0000-0002-6657-300X]
dc.contributor.orcidBeale, Mathew A [0000-0002-4740-3187]
dc.contributor.orcidSpencer Chapman, Michael [0000-0002-5320-8193]
dc.contributor.orcidJackson, David K [0000-0002-8090-9462]
dc.contributor.orcidPeacock, Sharon J [0000-0002-1718-2782]
dc.contributor.orcidGoodfellow, Ian G [0000-0002-9483-510X]
dc.contributor.orcidTorok, M Estee [0000-0001-9098-8590]
dc.identifier.eissn2050-084X
pubs.funder-project-idMedical Research Council (COG-UK MC-PC-19027)
pubs.funder-project-idNational Institute for Health Research (COG-UK MC-PC-19027)
pubs.funder-project-idWellcome Trust (COG-UK MC-PC-19027)
pubs.funder-project-idWellcome Trust (Senior Fellowship 097997/Z/11/Z)
pubs.funder-project-idAcademy of Medical Sciences (Clinician Scientist Fellowship)
pubs.funder-project-idHealth Foundation (Clinician Scientist Fellowship)
pubs.funder-project-idWellcome Trust (Collabrative grant 204870/Z/16/Z)


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