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Increased choroidal thickness in adults with Down syndrome.

Published version
Peer-reviewed

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Type

Article

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Authors

Csincsik, Lajos 
Nelson, Rachel 
Walpert, Madeleine J 
Peto, Tunde 

Abstract

INTRODUCTION: People with Down syndrome (DS) are particularly susceptible to Alzheimer's disease (AD) due to the triplication of the amyloid precursor protein (APP) gene. In this cross-sectional study, we hypothesized that choroidal thinning reported in sporadic AD (sAD) is mirrored in adults with DS. METHODS: The posterior pole of the eye for 24 adults with DS and 16 age-matched controls (Ctrl) were imaged with optical coherence tomography. Choroidal thickness (ChT) was measured and analyzed in relation to cognitive status and cerebral amyloid beta (Aβ) load. RESULTS: ChT was increased in people with DS (pwDS) compared to Ctrl. This increase was associated with gender differences and positively correlated with cerebral Aβ load in a small subset. There was no significant correlation detected between ChT and age or cognitive status. DISCUSSION: In contrast to sAD this study found a significantly thicker choroid in pwDS. Whether these changes are related to Aβ pathology in DS needs further investigation.

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Keywords

Alzheimer's disease, Down syndrome, biomarker, choroid, dementia, enhanced depth optical coherence tomography, posterior pole imaging

Journal Title

Alzheimers Dement (Amst)

Conference Name

Journal ISSN

2352-8729
2352-8729

Volume Title

13

Publisher

Wiley