Genetically predicted circulating B vitamins in relation to digestive system cancers.
British journal of cancer
Springer Nature [academic journals on nature.com]
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Yuan, S., Carter, P., Vithayathil, M., Kar, S., Mason, A., Burgess, S., & Larsson, S. C. (2021). Genetically predicted circulating B vitamins in relation to digestive system cancers.. British journal of cancer, 124 (12), 1997-2003. https://doi.org/10.1038/s41416-021-01383-0
Background: Folate, vitamin B6, and vitamin B12 have been associated with digestive system cancers. We conducted a two-sample Mendelian randomization study to assess the causality of these associations. Methods: Two, one and 14 independent single nucleotide polymorphisms associated with serum folate, vitamin B6, and vitamin B12 at the genome-wide significance threshold were selected as genetic instruments. Summary-level data for the associations of the vitamin-associated genetic variants with cancer were obtained from the UK Biobank study including 367 561 individuals and FinnGen consortium compromising up to 176 899 participants. Results: Genetically-predicted folate and vitamin B6 concentrations were not associated with overall cancer, overall digestive system cancer or esophageal, gastric, colorectal or pancreatic cancer. Genetically-predicted vitamin B12 concentrations were positively associated with overall digestive system cancer (ORSD, 1.12; 95% CI 1.04, 1.21, p=0.003) and colorectal cancer (ORSD 1.16; 95% CI 1.06, 1.26, p=0.001) in UK Biobank. Results for colorectal cancer were consistent in FinnGen and the combined ORSD was 1.16 (95% CI 1.08, 1.25, p<0.001). There was no association of genetically-predicted vitamin B12 with any other site-specific digestive system cancers or overall cancer. Conclusions: These results provide evidence to suggest that elevated serum vitamin B12 concentrations are associated with colorectal cancer.
Wellcome Trust (204623/Z/16/Z)
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External DOI: https://doi.org/10.1038/s41416-021-01383-0
This record's URL: https://www.repository.cam.ac.uk/handle/1810/319385
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