The catalytic stripper has emerged as a technology for removal of semi-volatile material from aerosol streams for automotive and aerospace emissions measurements, including portable solid particle emissions measurements governed by the Real Driving Emissions (RDE) regulations. This study employs coupled energy and mass transfer models to predict solid particle penetration and hydrocarbons removal for various configurations of a catalytic stripper. The continuum-scale macro model applies mass, momentum and energy conservation for the inlet heating region of a catalytic stripper whereby the catalyst monolith is represented by a porous medium. The particles and species dynamics inside the catalytic monolith were computed by coupled microsimulations of the monolith channel using boundary conditions from the macro model. The results from the numerical simulations were validated with corresponding experimental data and employed for a parametric study in terms of flow rate and catalyst length with a view to optimising the operating condition. Results of the simulation and experiment show that solid particle penetration through the catalytic stripper can exceed ~60% for particles at 10 nm mobility diameter and hydrocarbons removal of >95% for an optimized catalytic stripper device.