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dc.contributor.authorOakley, Bethany FM
dc.contributor.authorTillmann, Julian
dc.contributor.authorAhmad, Jumana
dc.contributor.authorCrawley, Daisy
dc.contributor.authorSan José Cáceres, Antonia
dc.contributor.authorHolt, Rosemary
dc.contributor.authorCharman, Tony
dc.contributor.authorBanaschewski, Tobias
dc.contributor.authorBuitelaar, Jan
dc.contributor.authorSimonoff, Emily
dc.contributor.authorMurphy, Declan
dc.contributor.authorLoth, Eva
dc.date.accessioned2021-04-10T17:25:18Z
dc.date.available2021-04-10T17:25:18Z
dc.date.issued2020-10-07
dc.identifier.issn1362-3613
dc.identifier.other10.1177_1362361320959959
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/319708
dc.description.abstractPrevious studies have reported reduced quality of life in autism. Improving quality of life for autistic people is, therefore, a key priority for clinical research and practice. However, the relative impact of core autism traits (e.g. social-communication difficulties), as compared to associated mental health symptoms (e.g. anxiety, depression) on quality of life remains poorly understood. This is despite at least 20%–50% of autistic individuals experiencing associated anxiety and/or depression symptoms. Hence, we measured subjective quality of life in 573 six to thirty-year-olds (autism spectrum disorder N = 344), using two widely validated questionnaires. Adults self-reported on the World Health Organization Quality of Life–Brief instrument. Parents of children/adolescents completed the Child Health and Illness Profile. We assessed individual variability across both measures and modelled associations between quality of life, core autism traits, anxiety, and depression symptoms. Across both age groups and quality of life measures, autistic individuals scored lower than comparison individuals, on average, particularly for physical health in adults (d = −1.24, 95% confidence interval: [−1.56, −0.93]) and school achievement for children/adolescents (d = −1.06, 95% confidence interval: [−1.29, −0.84]). However, a notable proportion of autistic individuals (36%–71% across quality of life domains) did not have reduced quality of life. Across ages and quality of life measures, severity of associated symptoms was significantly related to reduced quality of life on several domains, after accounting for core autism traits. Most notably, depression symptoms were related to reduced physical/psychological well-being in both adults (β ⩾ −0.34) and children/adolescents (β = −0.29, 95% confidence interval: [−0.36, −0.14]). For children/adolescents, anxiety symptoms (β ⩾ −0.28) and core social-communication difficulties (β ⩾ −0.22) were also related to subjective quality of life outcomes. Overall, findings indicate that not all autistic individuals experience reduced subjective quality of life. Variability in quality of life is significantly influenced by associated symptoms, across developmental stage. This may provide a tractable target for mental health services to improve quality of life for autistic individuals over the lifespan. Lay abstract: Previous studies suggest that some autistic individuals report lower satisfaction, or well-being, with different aspects of everyday life than those without autism. It is unclear whether this might be partly explained by symptoms of anxiety and/or depression, which affect at least 20%–50% of autistic people. In this study, we measured individual differences in well-being in 573 six to thirty-year-olds with and without a diagnosis of autism. We investigated whether individual differences in well-being were explained by autism traits (e.g. social-communication difficulties) and/or anxiety and depression symptoms. We showed that, though well-being was lower for some autistic individuals, compared to those without autism, many autistic individuals reported good well-being. Where well-being was reduced, this was particularly explained by depression symptoms, across all ages. For children/adolescents, anxiety and social-communication difficulties were also related to some aspects of well-being. Our study suggests that support and services for improving mental health, especially depression symptoms, may also improve broader outcomes for autistic people.
dc.languageen
dc.publisherSAGE Publications
dc.rightsEmbargo: ends 2020-10-07
dc.subjectOriginal Articles
dc.subjectanxiety
dc.subjectautism
dc.subjectdepression
dc.subjectquality of life
dc.subjectwell-being
dc.titleHow do core autism traits and associated symptoms relate to quality of life? Findings from the Longitudinal European Autism Project
dc.typeArticle
dc.date.updated2021-04-10T17:25:18Z
prism.endingPage404
prism.issueIdentifier2
prism.publicationNameAutism
prism.startingPage389
prism.volume25
dc.identifier.doi10.17863/CAM.66829
rioxxterms.versionofrecord10.1177/1362361320959959
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2020-10-07
dc.contributor.orcidOakley, Bethany FM [0000-0002-1968-134X]
dc.contributor.orcidCharman, Tony [0000-0003-1993-6549]
dc.contributor.orcidBanaschewski, Tobias [0000-0003-4595-1144]
dc.contributor.orcidSimonoff, Emily [0000-0002-5450-0823]
dc.identifier.eissn1461-7005
pubs.funder-project-idInnovative Medicines Initiative (115300 / 777394)
rioxxterms.freetoread.startdate2020-10-07


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