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dc.contributor.authorCanosa, Antonio
dc.contributor.authorCalvo, Andrea
dc.contributor.authorMoglia, Cristina
dc.contributor.authorManera, Umberto
dc.contributor.authorVasta, Rosario
dc.contributor.authorDi Pede, Francesca
dc.contributor.authorCabras, Sara
dc.contributor.authorNardo, Davide
dc.contributor.authorArena, Vincenzo
dc.contributor.authorGrassano, Maurizio
dc.contributor.authorD’Ovidio, Fabrizio
dc.contributor.authorVan Laere, Koen
dc.contributor.authorVan Damme, Philip
dc.contributor.authorPagani, Marco
dc.contributor.authorChiò, Adriano
dc.date.accessioned2021-04-12T15:46:45Z
dc.date.available2021-04-12T15:46:45Z
dc.date.issued2020-10-07
dc.date.submitted2020-06-08
dc.identifier.issn1619-7070
dc.identifier.others00259-020-05053-w
dc.identifier.other5053
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/319739
dc.description.abstractAbstract: Purpose: To assess the brain metabolic correlates of the different regional extent of ALS, evaluated with the King’s staging system, using brain 18F-2-fluoro-2-deoxy-d-glucose-PET (18F-FDG-PET). Methods: Three hundred ninety ALS cases with King’s stages 1, 2, and 3 (n = 390), i.e., involvement of 1, 2, and 3 body regions respectively, underwent brain 18F-FDG-PET at diagnosis. King’s stage at PET was derived from ALSFRS-R and was regressed out against whole-brain metabolism in the whole sample. The full factorial design confirmed the hypothesis that differences among groups (King’s 1, King’s 2, King’s 3, and 40 healthy controls (HC)) existed overall. Comparisons among stages and between each group and HC were performed. We included age at PET and sex as covariates. Results: Brain metabolism was inversely correlated with stage in medial frontal gyrus bilaterally, and right precentral and postcentral gyri. The full factorial design resulted in a significant main effect of groups. There was no significant difference between stages 1 and 2. Comparing stage 3 to stage 1+2, a significant relative hypometabolism was highlighted in the former in the left precentral and medial frontal gyri, and in the right medial frontal, postcentral, precentral, and middle frontal gyri. The comparisons between each group and HC showed the extension of frontal metabolic changes from stage 1 to stage 3, with the larger metabolic gap between stages 2 and 3. Conclusions: Our findings support the hypothesis that in ALS, the propagation of neurodegeneration follows a corticofugal, regional ordered pattern, extending from the motor cortex to posterior and anterior regions.
dc.languageen
dc.publisherSpringer Berlin Heidelberg
dc.subjectOriginal Article
dc.subjectNeurology
dc.subjectAmyotrophic lateral sclerosis
dc.subject18F-FDG-PET
dc.subjectKing’s staging system
dc.titleBrain metabolic changes across King’s stages in amyotrophic lateral sclerosis: a 18 F-2-fluoro-2-deoxy- d -glucose-positron emission tomography study
dc.typeArticle
dc.date.updated2021-04-12T15:46:45Z
prism.endingPage1133
prism.issueIdentifier4
prism.publicationNameEuropean Journal of Nuclear Medicine and Molecular Imaging
prism.startingPage1124
prism.volume48
dc.identifier.doi10.17863/CAM.66864
dcterms.dateAccepted2020-09-22
rioxxterms.versionofrecord10.1007/s00259-020-05053-w
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidCanosa, Antonio [0000-0001-5876-4079]
dc.identifier.eissn1619-7089
pubs.funder-project-idFondation Thierry Latran (INSPIRED Project, INSPIRED Project, INSPIRED Project, INSPIRED Project)
pubs.funder-project-idMinistero della Salute (RF-2016-02362405)
pubs.funder-project-idSeventh Framework Programme (259867)
pubs.funder-project-idMinistero dell’Istruzione, dell’Università e della Ricerca (PRIN 2017SNW5MB, The Joint Programme - Neurodegenerative Disease Research (Strength and Brain-Mend projects), Department of Excellence grant)


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