Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study.
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Authors
Jones, Danielle
Kusinski, Laura C
Hughes, Deborah J
Publication Date
2021-03-31Journal Title
Nutrients
ISSN
2072-6643
Publisher
MDPI AG
Volume
13
Issue
4
Language
eng
Type
Article
This Version
VoR
Physical Medium
Electronic
Metadata
Show full item recordCitation
Jones, D., De Lucia Rolfe, E., Rennie, K., Griep, L. M. O., Kusinski, L. C., Hughes, D. J., Brage, S., et al. (2021). Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study.. Nutrients, 13 (4) https://doi.org/10.3390/nu13041156
Abstract
Childhood obesity is an area of intense concern internationally and is influenced by events during antenatal and postnatal life. Although pregnancy complications, such as gestational diabetes and large-for-gestational-age birthweight have been associated with increased obesity risk in offspring, very few successful interventions in pregnancy have been identified. We describe a study protocol to identify if a reduced calorie diet in pregnancy can reduce adiposity in children to 3 years of age. The dietary intervention in gestational diabetes (DiGest) study is a randomised, controlled trial of a reduced calorie diet provided by a whole-diet replacement in pregnant women with gestational diabetes. Women receive a weekly dietbox intervention from enrolment until delivery and are blinded to calorie allocation. This follow-up study will assess associations between a reduced calorie diet in pregnancy with offspring adiposity and maternal weight and glycaemia. Anthropometry will be performed in infants and mothers at 3 months, 1, 2 and 3 years post-birth. Glycaemia will be assessed using bloodspot C-peptide in infants and continuous glucose monitoring with HbA1c in mothers. Data regarding maternal glycaemia in pregnancy, maternal nutrition, infant birthweight, offspring feeding behaviour and milk composition will also be collected. The DiGest follow-up study is expected to take 5 years, with recruitment finishing in 2026.
Keywords
Humans, Diabetes, Gestational, Body Weight, Blood Glucose, Clinical Protocols, Prenatal Care, Risk Factors, Follow-Up Studies, Life Style, Pregnancy, Adult, Child, Female, Maternal Nutritional Physiological Phenomena, Pediatric Obesity
Sponsorship
Diabetes UK (17/0005712)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Novo Nordisk Foundation (NNF19SA058974)
European Foundation for the Study of Diabetes (EFSD) (NNF19SA058974)
MRC (MC_UU_00006/2)
National Institute for Health Research (NIHRDH-IS-BRC-1215-20014)
Identifiers
External DOI: https://doi.org/10.3390/nu13041156
This record's URL: https://www.repository.cam.ac.uk/handle/1810/319777
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