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dc.contributor.authorJones, Danielle
dc.contributor.authorDe Lucia Rolfe, Emanuella
dc.contributor.authorRennie, Kirsten
dc.contributor.authorGriep, Linda M Oude
dc.contributor.authorKusinski, Laura C
dc.contributor.authorHughes, Deborah J
dc.contributor.authorBrage, Soren
dc.contributor.authorOng, Kenneth
dc.contributor.authorBeardsall, Kathryn
dc.contributor.authorMeek, Claire
dc.date.accessioned2021-04-12T23:31:29Z
dc.date.available2021-04-12T23:31:29Z
dc.date.issued2021-03-31
dc.identifier.issn2072-6643
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/319777
dc.description.abstractChildhood obesity is an area of intense concern internationally and is influenced by events during antenatal and postnatal life. Although pregnancy complications, such as gestational diabetes and large-for-gestational-age birthweight have been associated with increased obesity risk in offspring, very few successful interventions in pregnancy have been identified. We describe a study protocol to identify if a reduced calorie diet in pregnancy can reduce adiposity in children to 3 years of age. The dietary intervention in gestational diabetes (DiGest) study is a randomised, controlled trial of a reduced calorie diet provided by a whole-diet replacement in pregnant women with gestational diabetes. Women receive a weekly dietbox intervention from enrolment until delivery and are blinded to calorie allocation. This follow-up study will assess associations between a reduced calorie diet in pregnancy with offspring adiposity and maternal weight and glycaemia. Anthropometry will be performed in infants and mothers at 3 months, 1, 2 and 3 years post-birth. Glycaemia will be assessed using bloodspot C-peptide in infants and continuous glucose monitoring with HbA1c in mothers. Data regarding maternal glycaemia in pregnancy, maternal nutrition, infant birthweight, offspring feeding behaviour and milk composition will also be collected. The DiGest follow-up study is expected to take 5 years, with recruitment finishing in 2026.
dc.format.mediumElectronic
dc.languageeng
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectDiabetes, Gestational
dc.subjectBody Weight
dc.subjectBlood Glucose
dc.subjectClinical Protocols
dc.subjectPrenatal Care
dc.subjectRisk Factors
dc.subjectFollow-Up Studies
dc.subjectLife Style
dc.subjectPregnancy
dc.subjectAdult
dc.subjectChild
dc.subjectFemale
dc.subjectMaternal Nutritional Physiological Phenomena
dc.subjectPediatric Obesity
dc.titleAntenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study.
dc.typeArticle
prism.issueIdentifier4
prism.publicationDate2021
prism.publicationNameNutrients
prism.volume13
dc.identifier.doi10.17863/CAM.66902
dcterms.dateAccepted2021-03-29
rioxxterms.versionofrecord10.3390/nu13041156
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-03-31
dc.contributor.orcidDe Lucia Rolfe, Emanuella [0000-0003-3542-2767]
dc.contributor.orcidRennie, Kirsten [0000-0003-2690-1934]
dc.contributor.orcidGriep, Linda M Oude [0000-0001-7697-7473]
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
dc.contributor.orcidOng, Kenneth [0000-0003-4689-7530]
dc.contributor.orcidBeardsall, Kathryn [0000-0003-3582-183X]
dc.contributor.orcidMeek, Claire [0000-0002-4176-8329]
dc.identifier.eissn2072-6643
rioxxterms.typeJournal Article/Review
pubs.funder-project-idDiabetes UK (17/0005712)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idNovo Nordisk Foundation (NNF19SA058974)
pubs.funder-project-idEuropean Foundation for the Study of Diabetes (EFSD) (NNF19SA058974)
cam.issuedOnline2021-03-31


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International