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dc.contributor.authorRubinsztein, Daviden
dc.contributor.authorPavel, Marianaen
dc.contributor.authorPark, So Jungen
dc.contributor.authorFrake, Rebeccaen
dc.contributor.authorSon, Sungminen
dc.contributor.authorManni, Marcoen
dc.contributor.authorBento, Carlaen
dc.contributor.authorRenna, Maurizioen
dc.contributor.authorRicketts, Thomasen
dc.contributor.authorMenzies, Fionaen
dc.contributor.authorTanasa, Raduen
dc.date.accessioned2021-04-14T13:08:53Z
dc.date.available2021-04-14T13:08:53Z
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/319863
dc.description.abstractThe factors regulating cellular identity are critical for understanding the transition from health to disease and responses to therapies. Recent literature suggests that autophagy compromise may cause opposite effects in different contexts by either activating or inhibiting YAP/TAZ co-transcriptional regulators of the Hippo pathway via unrelated mechanisms. Here, we report that autophagy perturbation in different cell types can have opposite responses in growth-promoting oncogenic YAP/TAZ transcriptional signalling. These apparently contradictory responses can be resolved by a feedback loop where autophagy negatively regulates the levels of α-catenins LC3-interacting proteins, which inhibit YAP/TAZ, which, in turn, positively regulate autophagy. High basal levels of α-catenins enable autophagy induction to positively regulate YAP/TAZ, while low α-catenins cause YAP/TAZ activation upon autophagy inhibition. These data reveal how feedback loops enable post-transcriptional determination of cell identity and how levels of a single intermediary protein can dictate the direction of response to external or internal perturbations.
dc.publisherNature Research
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleα-Catenin Levels Determine Direction of YAP/TAZ Response to Autophagy Perturbationen
dc.typeArticle
prism.publicationNameNature Communicationsen
dc.identifier.doi10.17863/CAM.66988
dcterms.dateAccepted2021-02-18en
rioxxterms.versionofrecord10.1038/s41467-021-21882-1en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-02-18en
dc.contributor.orcidRubinsztein, David [0000-0001-5002-5263]
dc.contributor.orcidSon, Sungmin [0000-0002-3536-1952]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (095317/Z/11/Z)
pubs.funder-project-idWellcome Trust (100140/Z/12/Z)
cam.issuedOnline2021-03-17en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International