Decision-making ability, psychopathology, and brain connectivity.
Dolan, Raymond J
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Moutoussis, M., Garzón, B., Neufeld, S., Bach, D. R., Rigoli, F., Goodyer, I., Bullmore, E., et al. (2021). Decision-making ability, psychopathology, and brain connectivity.. Neuron, 109 (12), 2025-2040.e7. https://doi.org/10.1016/j.neuron.2021.04.019
Decision-making is a cognitive process of central importance for the quality of our lives. Here, we ask if a common factor underpins our diverse decision-making abilities. We obtained 32 decision-making measures from 830 young people and identified a common factor that we call `decision acuity’, which was distinct from IQ and reflected a generic decision-making ability. Decision acuity was decreased in those with aberrant thinking and low general social functioning. Crucially, decision acuity and IQ had dissociable brain signatures, in terms of their associated neural networks of resting-state functional connectivity. Decision acuity was reliably measured, and its relationship with functional connectivity was also stable when measured in the same individuals 18 months later. Thus, our behavioural and brain data identify a new cognitive construct that underpins decision-making ability across multiple domains. This construct may be important for understanding mental health, particularly regarding poor social function and aberrant thought patterns.
NSPN Consortium, Brain, Neural Pathways, Humans, Magnetic Resonance Imaging, Factor Analysis, Statistical, Depression, Affect, Anxiety, Self Concept, Cognition, Decision Making, Depressive Disorder, Major, Antisocial Personality Disorder, Intelligence Tests, Neuropsychological Tests, Adolescent, Female, Male, Young Adult, Functional Neuroimaging, Social Interaction, Psychosocial Functioning
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Department of Health (via National Institute for Health Research (NIHR)) (156239)
Wellcome Trust (095844/Z/11/Z)
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External DOI: https://doi.org/10.1016/j.neuron.2021.04.019
This record's URL: https://www.repository.cam.ac.uk/handle/1810/321365
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/