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dc.contributor.authorBandara, Y
dc.contributor.authorBayton, WA
dc.contributor.authorWilliams, Timothy
dc.contributor.authorScase, T
dc.contributor.authorBexfield, NH
dc.date.accessioned2021-04-21T23:30:08Z
dc.date.available2021-04-21T23:30:08Z
dc.date.issued2021-09
dc.identifier.issn0022-4510
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/321398
dc.description.abstractOBJECTIVES: Canine hepatobiliary disease is common; however, data determining disease frequency and breed predispositions are lacking. The primary objective was to identify the frequency of different hepatobiliary disease in a United Kingdom population of dogs and consequently determine breeds at both an increased and decreased risk of hepatobiliary disease. MATERIALS AND METHODS: Anonymised histopathology reports from a commercial veterinary diagnostic laboratory, which were submitted between August 2013 and February 2018, were analysed. Data were retrospectively categorised into hepatobiliary diseases according to World Small Animal Veterinary Association Standards and the breed, age and genders recorded. Cases with incomplete data or no definitive diagnosis were excluded. Breed predisposition was calculated using odds ratios and 95% confidence intervals against a United Kingdom-based control population of micro-chipped dogs. RESULTS: Histopathology results from 4584 cases met inclusion criteria. The most frequent histological diagnoses were reactive hepatitis (n=770); chronic hepatitis (n=735) and reversible hepatocellular injury (n=589). A number of breeds were shown to be at an increased or decreased risk of individual liver diseases. CLINICAL SIGNIFICANCE: This is the first study to document the histopathological frequency of hepatobiliary diseases in a large cohort of dogs in the United Kingdom, as well as novel possible breed and age predispositions. Despite multivariable analysis not being performed to account for confounding factors, this information hopes to inform and support future investigations for hepatic disease in particular breeds and potential predispositions.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.rightsAll rights reserved
dc.subjectAnimals
dc.subjectDogs
dc.subjectLiver Diseases
dc.subjectHepatitis, Chronic
dc.subjectDog Diseases
dc.subjectRetrospective Studies
dc.subjectGenotype
dc.subjectFemale
dc.subjectMale
dc.subjectUnited Kingdom
dc.titleHistopathological frequency of canine hepatobiliary disease in the United Kingdom.
dc.typeArticle
prism.endingPage736
prism.issueIdentifier9
prism.publicationDate2021
prism.publicationNameJ Small Anim Pract
prism.startingPage730
prism.volume62
dc.identifier.doi10.17863/CAM.68519
dcterms.dateAccepted2021-04-18
rioxxterms.versionofrecord10.1111/jsap.13354
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-09
dc.contributor.orcidWilliams, Timothy [0000-0002-9775-8285]
dc.identifier.eissn1748-5827
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-06-21
cam.orpheus.successMon Jul 05 07:31:10 BST 2021 - Embargo updated
cam.orpheus.counter10
rioxxterms.freetoread.startdate2022-06-21


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