Synthetic Enzyme-Catalyzed CO2 Fixation Reactions.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Aleku, Godwin A
Roberts, George W
Titchiner, Gabriel R
Leys, David
Abstract
In recent years, (de)carboxylases that catalyze reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof-of-concept (bio)synthetic CO2 fixation routes for chemical production. However, further progress towards industrial application has been hampered by the thermodynamic constraint that accompanies fixing CO2 to organic molecules. In this Review, biocatalytic carboxylation methods are discussed with emphases on the diverse strategies devised to alleviate the inherent thermodynamic constraints and their application in synthetic CO2 -fixation cascades.
Description
Keywords
CO2 fixation, enzymes, biocatalysis, carboxylation, cascade reactions, Biocatalysis, Biotin, Carbon Dioxide, Carboxy-Lyases, Dinitrocresols, Metals, Molecular Structure, Pyridoxal, Structure-Activity Relationship, Thermodynamics, Thiamine Pyrophosphate
Journal Title
ChemSusChem
Conference Name
Journal ISSN
1864-5631
1864-564X
1864-564X
Volume Title
14
Publisher
Wiley
Publisher DOI
Sponsorship
Leverhulme Trust (ECF-2020-694)