Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND)—a systems neuroscience approach to common developmental disorders
Johnson, Mark H.
Jones, Emily J. H.
Journal of Child Psychology and Psychiatry
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Johnson, M. H., Charman, T., Pickles, A., & Jones, E. J. H. (2021). Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND)—a systems neuroscience approach to common developmental disorders. Journal of Child Psychology and Psychiatry, 62 (5), 610-630. https://doi.org/10.1111/jcpp.13372
Funder: UK Medical Research Council Programme Grant MR/T003057/1; Id: http://dx.doi.org/10.13039/501100000265
We present the Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) framework, designed to reframe the field of prospective studies of neurodevelopmental disorders. In AMEND we propose conceptual, statistical and methodological approaches to separating markers of early‐stage perturbations from later developmental modifiers. We describe the evidence for, and features of, these interacting components before outlining analytical approaches to studying how different profiles of early perturbations and later modifiers interact to produce phenotypic outcomes. We suggest this approach could both advance our theoretical understanding and clinical approach to the emergence of developmental psychopathology in early childhood.
Annual Research Review, Neurodevelopmental disorders, autism spectrum disorders, brain development
External DOI: https://doi.org/10.1111/jcpp.13372
This record's URL: https://www.repository.cam.ac.uk/handle/1810/321647