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dc.contributor.authorJohnson, Mark H.
dc.contributor.authorCharman, Tony
dc.contributor.authorPickles, Andrew
dc.contributor.authorJones, Emily J. H.
dc.date.accessioned2021-04-27T15:30:36Z
dc.date.available2021-04-27T15:30:36Z
dc.date.issued2021-01-11
dc.identifier.issn0021-9630
dc.identifier.issn1469-7610
dc.identifier.otherjcpp13372
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/321647
dc.descriptionFunder: UK Medical Research Council Programme Grant MR/T003057/1; Id: http://dx.doi.org/10.13039/501100000265
dc.description.abstractWe present the Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) framework, designed to reframe the field of prospective studies of neurodevelopmental disorders. In AMEND we propose conceptual, statistical and methodological approaches to separating markers of early‐stage perturbations from later developmental modifiers. We describe the evidence for, and features of, these interacting components before outlining analytical approaches to studying how different profiles of early perturbations and later modifiers interact to produce phenotypic outcomes. We suggest this approach could both advance our theoretical understanding and clinical approach to the emergence of developmental psychopathology in early childhood.
dc.languageen
dc.subjectAnnual Research Review
dc.subjectNeurodevelopmental disorders
dc.subjectautism spectrum disorders
dc.subjectbrain development
dc.titleAnnual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND)—a systems neuroscience approach to common developmental disorders
dc.typeArticle
dc.date.updated2021-04-27T15:30:36Z
prism.endingPage630
prism.issueIdentifier5
prism.publicationNameJournal of Child Psychology and Psychiatry
prism.startingPage610
prism.volume62
dc.identifier.doi10.17863/CAM.68765
dcterms.dateAccepted2020-11-25
rioxxterms.versionofrecord10.1111/jcpp.13372
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidCharman, Tony [0000-0003-1993-6549]


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