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dc.contributor.authorGillett, Daniel
dc.contributor.authorMarsden, Daniel
dc.contributor.authorBallout, Safia
dc.contributor.authorAttili, Bala
dc.contributor.authorBird, Nick
dc.contributor.authorHeard, Sarah
dc.contributor.authorGurnell, Mark
dc.contributor.authorMendichovszky, Iosif A.
dc.contributor.authorAloj, Luigi
dc.date.accessioned2021-04-28T15:13:40Z
dc.date.available2021-04-28T15:13:40Z
dc.date.issued2021-04-28
dc.date.submitted2020-12-23
dc.identifier.others40658-021-00383-6
dc.identifier.other383
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/321687
dc.description.abstractAbstract: Purpose: Phantoms are routinely used in molecular imaging to assess scanner performance. However, traditional phantoms with fillable shapes do not replicate human anatomy. 3D-printed phantoms have overcome this by creating phantoms which replicate human anatomy which can be filled with radioactive material. The problem with these is that small objects suffer to a greater extent than larger objects from the effects of inactive walls, and therefore, phantoms without these are desirable. The purpose of this study was to explore the feasibility of creating resin-based 3D-printed phantoms using 18F. Methods: Radioactive resin was created using an emulsion of printer resin and 18F-FDG. A series of test objects were printed including twenty identical cylinders, ten spheres with increasing diameters (2 to 20 mm), and a double helix. Radioactive concentration uniformity, printing accuracy and the amount of leaching were assessed. Results: Creating radioactive resin was simple and effective. The radioactive concentration was uniform among identical objects; the CoV of the signal was 0.7% using a gamma counter. The printed cylinders and spheres were found to be within 4% of the model dimensions. A double helix was successfully printed as a test for the printer and appeared as expected on the PET scanner. The amount of radioactivity leached into the water was measurable (0.72%) but not visible above background on the imaging. Conclusions: Creating an 18F radioactive resin emulsion is a simple and effective way to create accurate and complex phantoms without inactive walls. This technique could be used to print clinically realistic phantoms. However, they are single use and cannot be made hollow without an exit hole. Also, there is a small amount of leaching of the radioactivity to take into consideration.
dc.languageen
dc.publisherSpringer International Publishing
dc.subjectOriginal Research
dc.subjectPET
dc.subject3D printing
dc.subjectPhantoms
dc.subjectQuality control
dc.subject18F
dc.title3D printing 18 F radioactive phantoms for PET imaging
dc.typeArticle
dc.date.updated2021-04-28T15:13:39Z
prism.issueIdentifier1
prism.publicationNameEJNMMI Physics
prism.volume8
dc.identifier.doi10.17863/CAM.68807
dcterms.dateAccepted2021-04-13
rioxxterms.versionofrecord10.1186/s40658-021-00383-6
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidGillett, Daniel [0000-0002-9773-6502]
dc.identifier.eissn2197-7364
pubs.funder-project-idAddenbrooke's Charitable Trust, Cambridge University Hospitals (900158)
pubs.funder-project-idNational Institute for Health Research (BRC-1215-20014)


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