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Current and emerging therapeutic approaches for T‐cell acute lymphoblastic leukaemia

Published version
Peer-reviewed

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Abstract

Summary: T‐cell ALL (T‐ALL) is an aggressive malignancy of T‐cell progenitors. Although survival outcomes in T‐ALL have greatly improved over the past 50 years, relapsed and refractory cases remain extremely challenging to treat and those who cannot tolerate intensive treatment continue to have poor outcomes. Furthermore, T‐ALL has proven a more challenging immunotherapeutic target than B‐ALL. In this review we explore our expanding knowledge of the basic biology of T‐ALL and how this is paving the way for repurposing established treatments and the development of novel therapeutic approaches.

Description

Funder: Great Ormond Street Hospital Children's Charity


Funder: Blood Cancer UK Bennett Fellowship


Funder: Biomedical Research Council Fellowship

Keywords

Review, Reviews, leukaemia, novel treatments

Journal Title

British Journal of Haematology

Conference Name

Journal ISSN

0007-1048
1365-2141

Volume Title

Publisher

Sponsorship
Kay Kendall Leukaemia Fund (553577)
Cancer Research UK (C67279/A27957)
Wellcome Trust (203151/Z/16/Z)