Genomic landscape of platinum resistant and sensitive testicular cancers
Proszek, Paula Z.
Cornish, Alex J.
Bakir, Maise Al
Nature Publishing Group UK
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Loveday, C., Litchfield, K., Proszek, P. Z., Cornish, A. J., Santo, F., Levy, M., Macintyre, G., et al. (2020). Genomic landscape of platinum resistant and sensitive testicular cancers. Nature Communications, 11 (1)https://doi.org/10.1038/s41467-020-15768-x
Abstract: While most testicular germ cell tumours (TGCTs) exhibit exquisite sensitivity to platinum chemotherapy, ~10% are platinum resistant. To gain insight into the underlying mechanisms, we undertake whole exome sequencing and copy number analysis in 40 tumours from 26 cases with platinum-resistant TGCT, and combine this with published genomic data on an additional 624 TGCTs. We integrate analyses for driver mutations, mutational burden, global, arm-level and focal copy number (CN) events, and SNV and CN signatures. Albeit preliminary and observational in nature, these analyses provide support for a possible mechanistic link between early driver mutations in RAS and KIT and the widespread copy number events by which TGCT is characterised.
Article, /631/67/68, /631/67/1836, /45, /45/23, /49/61, article
External DOI: https://doi.org/10.1038/s41467-020-15768-x
This record's URL: https://www.repository.cam.ac.uk/handle/1810/321921