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dc.contributor.authorPerera, Marianne R
dc.contributor.authorWills, Mark
dc.contributor.authorSinclair, John
dc.date.accessioned2021-05-05T23:30:13Z
dc.date.available2021-05-05T23:30:13Z
dc.date.issued2021-05-01
dc.identifier.issn1999-4915
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/322002
dc.description.abstractHuman cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. In healthy people, primary infection is generally asymptomatic, and the virus can go on to establish lifelong latency in cells of the myeloid lineage. However, HCMV often causes severe disease in the immunosuppressed: transplant recipients and people living with AIDS, and also in the immunonaive foetus. At present, there are several antiviral drugs licensed to control HCMV disease. However, these are all faced with problems of poor bioavailability, toxicity and rapidly emerging viral resistance. Furthermore, none of them are capable of fully clearing the virus from the host, as they do not target latent infection. Consequently, reactivation from latency is a significant source of disease, and there remains an unmet need for treatments that also target latent infection. This review briefly summarises the most common HCMV antivirals used in clinic at present and discusses current research into targeting the latent HCMV reservoir.
dc.description.sponsorshipThis research was funded by the Medical Research Council (MRC) Programme Grant (grant number MR/S00081X/1) and an MRC Doctoral Training grant to M.R.P. (grant number RG86932).
dc.format.mediumElectronic
dc.languageeng
dc.publisherMDPI AG
dc.rightsAll rights reserved
dc.subjectHumans
dc.subjectCytomegalovirus
dc.subjectCytomegalovirus Infections
dc.subjectDisease Susceptibility
dc.subjectAntiviral Agents
dc.subjectOrgan Transplantation
dc.subjectDisease Reservoirs
dc.subjectVirus Latency
dc.subjectVirus Activation
dc.subjectDrug Development
dc.titleHCMV Antivirals and Strategies to Target the Latent Reservoir.
dc.typeArticle
prism.issueIdentifier5
prism.publicationDate2021
prism.publicationNameViruses
prism.volume13
dc.identifier.doi10.17863/CAM.69460
dcterms.dateAccepted2021-04-28
rioxxterms.versionofrecord10.3390/v13050817
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-05
dc.contributor.orcidPerera, Marianne R [0000-0001-9175-0568]
dc.contributor.orcidWills, Mark [0000-0001-8548-5729]
dc.contributor.orcidSinclair, John [0000-0002-2616-9571]
dc.identifier.eissn1999-4915
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/S00081X/1)
cam.issuedOnline2021-05-01


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