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dc.contributor.authorPerera, Marianne Ren
dc.contributor.authorWills, Marken
dc.contributor.authorSinclair, Johnen
dc.date.accessioned2021-05-05T23:30:13Z
dc.date.available2021-05-05T23:30:13Z
dc.date.issued2021-05en
dc.identifier.issn1999-4915
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/322002
dc.description.abstractHuman cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. In healthy people, primary infection is generally asymptomatic, and the virus can go on to establish lifelong latency in cells of the myeloid lineage. However, HCMV often causes severe disease in the immunosuppressed: transplant recipients and people living with AIDS, and also in the immunonaive foetus. At present, there are several antiviral drugs licensed to control HCMV disease. However, these are all faced with problems of poor bioavailability, toxicity and rapidly emerging viral resistance. Furthermore, none of them are capable of fully clearing the virus from the host, as they do not target latent infection. Consequently, reactivation from latency is a significant source of disease, and there remains an unmet need for treatments that also target latent infection. This review briefly summarises the most common HCMV antivirals used in clinic at present and discusses current research into targeting the latent HCMV reservoir.
dc.description.sponsorshipThis research was funded by the Medical Research Council (MRC) Programme Grant (grant number MR/S00081X/1) and an MRC Doctoral Training grant to M.R.P. (grant number RG86932).
dc.format.mediumElectronicen
dc.languageengen
dc.publisherMDPI AG
dc.rightsAll rights reserved
dc.subjectHumansen
dc.subjectCytomegalovirusen
dc.subjectCytomegalovirus Infectionsen
dc.subjectDisease Susceptibilityen
dc.subjectAntiviral Agentsen
dc.subjectOrgan Transplantationen
dc.subjectDisease Reservoirsen
dc.subjectVirus Latencyen
dc.subjectVirus Activationen
dc.subjectDrug Developmenten
dc.titleHCMV Antivirals and Strategies to Target the Latent Reservoir.en
dc.typeArticle
prism.issueIdentifier5en
prism.publicationDate2021en
prism.publicationNameVirusesen
prism.volume13en
dc.identifier.doi10.17863/CAM.69460
dcterms.dateAccepted2021-04-28en
rioxxterms.versionofrecord10.3390/v13050817en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-05en
dc.contributor.orcidPerera, Marianne R [0000-0001-9175-0568]
dc.contributor.orcidWills, Mark [0000-0001-8548-5729]
dc.contributor.orcidSinclair, John [0000-0002-2616-9571]
dc.identifier.eissn1999-4915
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/S00081X/1)


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