Electronics with shape actuation for minimally invasive spinal cord stimulation.
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Authors
Yu, Yi-Lin
Martínez-Domínguez, Héctor
Publication Date
2021-06Journal Title
Sci Adv
ISSN
2375-2548
Publisher
American Association for the Advancement of Science (AAAS)
Volume
7
Issue
26
Language
eng
Type
Article
This Version
VoR
Physical Medium
Electronic-Print
Metadata
Show full item recordCitation
Woodington, B. J., Curto, V. F., Yu, Y., Martínez-Domínguez, H., Coles, L., Malliaras, G., Proctor, C., & et al. (2021). Electronics with shape actuation for minimally invasive spinal cord stimulation.. Sci Adv, 7 (26) https://doi.org/10.1126/sciadv.abg7833
Abstract
Spinal cord stimulation is one of the oldest and most established neuromodulation therapies. However, today, clinicians need to choose between bulky paddle-type devices, requiring invasive surgery under general anesthetic, and percutaneous lead-type devices, which can be implanted via simple needle puncture under local anesthetic but offer clinical drawbacks when compared with paddle devices. By applying photo- and soft lithography fabrication, we have developed a device that features thin, flexible electronics and integrated fluidic channels. This device can be rolled up into the shape of a standard percutaneous needle then implanted on the site of interest before being expanded in situ, unfurling into its paddle-type conformation. The device and implantation procedure have been validated in vitro and on human cadaver models. This device paves the way for shape-changing bioelectronic devices that offer a large footprint for sensing or stimulation but are implanted in patients percutaneously in a minimally invasive fashion.
Relationships
URI: https://creativecommons.org/licenses/by/4.0/
Sponsorship
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (732032)
Sir Jules Thorn Charitable Trust (233838)
Engineering and Physical Sciences Research Council (EP/L015889/1)
EPSRC (EP/S023046/1)
Identifiers
External DOI: https://doi.org/10.1126/sciadv.abg7833
This record's URL: https://www.repository.cam.ac.uk/handle/1810/322076
Rights
Creative Commons Attribution License 4.0 (CC BY)
Licence:
http://www.rioxx.net/licenses/all-rights-reserved
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