Electronics with shape actuation for minimally invasive spinal cord stimulation.
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Peer-reviewed
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Abstract
Spinal cord stimulation is one of the oldest and most established neuromodulation therapies. However, today, clinicians need to choose between bulky paddle-type devices, requiring invasive surgery under general anesthetic, and percutaneous lead-type devices, which can be implanted via simple needle puncture under local anesthetic but offer clinical drawbacks when compared with paddle devices. By applying photo- and soft lithography fabrication, we have developed a device that features thin, flexible electronics and integrated fluidic channels. This device can be rolled up into the shape of a standard percutaneous needle then implanted on the site of interest before being expanded in situ, unfurling into its paddle-type conformation. The device and implantation procedure have been validated in vitro and on human cadaver models. This device paves the way for shape-changing bioelectronic devices that offer a large footprint for sensing or stimulation but are implanted in patients percutaneously in a minimally invasive fashion.
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2375-2548
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Sir Jules Thorn Charitable Trust (233838)
Engineering and Physical Sciences Research Council (EP/L015889/1)
EPSRC (EP/S023046/1)
BBSRC (BB/T009314/1)
Engineering and Physical Sciences Research Council (2259381)