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Electronics with shape actuation for minimally invasive spinal cord stimulation.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Yu, Yi-Lin 
Martínez-Domínguez, Héctor 

Abstract

Spinal cord stimulation is one of the oldest and most established neuromodulation therapies. However, today, clinicians need to choose between bulky paddle-type devices, requiring invasive surgery under general anesthetic, and percutaneous lead-type devices, which can be implanted via simple needle puncture under local anesthetic but offer clinical drawbacks when compared with paddle devices. By applying photo- and soft lithography fabrication, we have developed a device that features thin, flexible electronics and integrated fluidic channels. This device can be rolled up into the shape of a standard percutaneous needle then implanted on the site of interest before being expanded in situ, unfurling into its paddle-type conformation. The device and implantation procedure have been validated in vitro and on human cadaver models. This device paves the way for shape-changing bioelectronic devices that offer a large footprint for sensing or stimulation but are implanted in patients percutaneously in a minimally invasive fashion.

Description

Keywords

40 Engineering, 4003 Biomedical Engineering, Bioengineering, Assistive Technology, 5 Development of treatments and therapeutic interventions, 5.3 Medical devices

Journal Title

Sci Adv

Conference Name

Journal ISSN

2375-2548
2375-2548

Volume Title

7

Publisher

American Association for the Advancement of Science (AAAS)

Rights

Creative Commons Attribution License 4.0 (CC BY)
Sponsorship
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (732032)
Sir Jules Thorn Charitable Trust (233838)
Engineering and Physical Sciences Research Council (EP/L015889/1)
EPSRC (EP/S023046/1)
BBSRC (BB/T009314/1)
Engineering and Physical Sciences Research Council (2259381)