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dc.contributor.authorWoodington, Ben Jen
dc.contributor.authorCurto, Vincenzo Fen
dc.contributor.authorYu, Yi-Linen
dc.contributor.authorMartínez-Domínguez, Héctoren
dc.contributor.authorColes, Lawrenceen
dc.contributor.authorMalliaras, Georgeen
dc.contributor.authorProctor, Christopheren
dc.contributor.authorBarone, Damianoen
dc.date.accessioned2021-05-06T23:30:46Z
dc.date.available2021-05-06T23:30:46Z
dc.date.issued2021-06-25en
dc.identifier.issn2375-2548
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/322076
dc.description.abstractSpinal cord stimulation is one of the oldest and most established neuromodulation therapies. But today, clinicians need to choose between bulky paddle-type devices, requiring invasive surgery under general anesthetic, and percutaneous lead-type devices, which can be implanted via simple needle puncture under local anesthetic, but offer technical and clinical drawbacks when compared with paddle devices. By applying a combination of photo- and soft-lithography fabrication we have developed a device which features thin, flexible electronics and integrated fluidic channels. This device can be rolled up into the shape of a standard percutaneous needle then implanted on the site of interest before being expanded in situ, unfurling into its paddle type conformation. The device and implantation procedure have been validated in vitro and on a human cadaver model. The development of this device paves the way for shape-changing bioelectronic devices that offer a large footprint for sensing or stimulation but are introduced percutaneously to the patient in a minimally invasive fashion.
dc.format.mediumElectronic-Printen
dc.languageengen
dc.publisherAmerican Association for the Advancement of Science
dc.rightsAll rights reserved
dc.rights.uri
dc.titleElectronics with shape actuation for minimally invasive spinal cord stimulation.en
dc.typeArticle
prism.issueIdentifier26en
prism.publicationDate2021en
prism.publicationNameScience advancesen
prism.volume7en
dc.identifier.doi10.17863/CAM.69535
dcterms.dateAccepted2021-05-13en
rioxxterms.versionofrecord10.1126/sciadv.abg7833en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-06-25en
dc.contributor.orcidWoodington, Ben J [0000-0002-8878-5644]
dc.contributor.orcidCurto, Vincenzo F [0000-0002-0571-7903]
dc.contributor.orcidColes, Lawrence [0000-0002-4288-9691]
dc.contributor.orcidMalliaras, Georgios [0000-0002-4582-8501]
dc.contributor.orcidProctor, Christopher [0000-0002-2066-1354]
dc.contributor.orcidBarone, Damiano [0000-0002-0091-385X]
dc.identifier.eissn2375-2548
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (732032)
pubs.funder-project-idSir Jules Thorn Charitable Trust (233838)
pubs.funder-project-idEPSRC (EP/L015889/1)
pubs.funder-project-idEPSRC (EP/S023046/1)
cam.orpheus.counter8*
rioxxterms.freetoread.startdate2024-05-06


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