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dc.contributor.authorXu, Ruiling
dc.contributor.authorPauley, Tara Alicia
dc.contributor.authorMissfelder-Lobos, Hannah
dc.contributor.authorHaddon, Richard John
dc.contributor.authorGupta, Ravindra Kumar
dc.contributor.authorChong, Hsu Phern
dc.date.accessioned2021-05-10T23:30:20Z
dc.date.available2021-05-10T23:30:20Z
dc.date.issued2021-03-17
dc.identifier.issn1471-2393
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/322203
dc.description.abstractBACKGROUND: Asymptomatic carriage of COVID-19 in pregnant women has been reported and could lead to outbreaks in maternity units. We sought to ascertain the impact of rapid isothernal nucleic acid based testing for COVID-19 in an unselected cohort of pregnant women attending our maternity unit. We also assessed the correlation between community prevalence and asymptomatic carriage. METHODS: Data for the retrospective cohort study were collected from a large UK tertiary maternity unit over a 4-week period using computerised hospital records. Literature searches were performed across multiple repositories. COVID-19 prevalence was extracted from online repositories. RESULTS: Nasopharyngeal and oropharyngeal swabs were obtained from 457/465 (98%) women during the study period. The median turnaround time for results was 5.3 h (interquartile range (IQR) 2.6-8.9 h), with 92% of the results returned within 24 h. In our cohort, only one woman tested positive, giving a screen positive rate of 0.22% (1/457; 95% CI: 0.04-1.23%). One woman who tested negative developed a fever postnatally following discharge but was lost to follow-up. From our literature review, we did not find any correlation between asymptomatic carriage in pregnant women and the reported regional prevalence of COVID-19. CONCLUSIONS: Testing using the SAMBA-II machine was acceptable to the vast majority of pregnant women requiring admission and had a low turnaround time. Asymptomatic carriage is low, but not correlated to community prevalence rates. Screening pregnant women on admission will remain an important component in order to minimise nosocomial infection.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectCross Infection
dc.subjectPregnancy Complications, Infectious
dc.subjectMass Screening
dc.subjectRetrospective Studies
dc.subjectCohort Studies
dc.subjectCarrier State
dc.subjectPregnancy
dc.subjectTime Factors
dc.subjectHospitals, Maternity
dc.subjectFemale
dc.subjectPoint-of-Care Testing
dc.subjectUnited Kingdom
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectCOVID-19 Nucleic Acid Testing
dc.titleSamba II PCR testing for COVID-19 in pregnant women: a retrospective cohort study and literature review.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2021
prism.publicationNameBMC Pregnancy Childbirth
prism.startingPage212
prism.volume21
dc.identifier.doi10.17863/CAM.69662
dcterms.dateAccepted2021-02-18
rioxxterms.versionofrecord10.1186/s12884-021-03653-4
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-03-17
dc.contributor.orcidChong, Hsu Phern [0000-0002-4662-3882]
dc.identifier.eissn1471-2393
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-03-17


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International