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Conserved features of non-primate bilaminar disc embryos and the germline.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Alberio, Ramiro 
Kobayashi, Toshihiro 
Surani, M Azim 

Abstract

Post-implantation embryo development commences with a bilaminar disc in most mammals, including humans. Whereas access to early human embryos is limited and subject to greater ethical scrutiny, studies on non-primate embryos developing as bilaminar discs offer exceptional opportunities for advances in gastrulation, the germline, and the basis for evolutionary divergence applicable to human development. Here, we discuss the advantages of investigations in the pig embryo as an exemplar of development of a bilaminar disc embryo with relevance to early human development. Besides, the pig has the potential for the creation of humanized organs for xenotransplantation. Precise genetic engineering approaches, imaging, and single-cell analysis are cost effective and efficient, enabling research into some outstanding questions on human development and for developing authentic models of early human development with stem cells.

Description

Keywords

embryogenesis, embryonic disc, epigenetic reprogramming, mammalian development, primordial germ cells, Animals, Embryo, Mammalian, Epigenesis, Genetic, Gene Regulatory Networks, Germ Cells, Humans, Mammals, Models, Biological

Journal Title

Stem Cell Reports

Conference Name

Journal ISSN

2213-6711
2213-6711

Volume Title

16

Publisher

Elsevier BV
Sponsorship
BBSRC (BB/T01346X/1)
Medical Research Council (MR/P009948/1)