Antenatal Exposure to UV-B Radiation and Preeclampsia: A Retrospective Cohort Study.
Hastie, Claire E
Mackay, Daniel F
Clemens, Tom L
Cherrie, Mark PC
Megaw, Lauren J
Stock, Sarah J
Pell, Jill P
Journal of the American Heart Association
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Hastie, C. E., Mackay, D. F., Clemens, T. L., Cherrie, M. P., Megaw, L. J., Smith, G., Stock, S. J., et al. (2021). Antenatal Exposure to UV-B Radiation and Preeclampsia: A Retrospective Cohort Study.. Journal of the American Heart Association, 10 (13), e020246. https://doi.org/10.1161/jaha.120.020246
Abstract Background Risk of pre-eclampsia varies by month of delivery. We tested whether this seasonal patterning may be mediated through maternal vitamin D concentration using antenatal exposure to ultraviolet B radiation as an instrumental variable. Methods and Results Scottish maternity records were linked to antenatal ultraviolet B exposure derived from satellites between 2000 and 2010. Logistic regression analyses were used to explore the association between ultraviolet B and pre-eclampsia, adjusting for the potential confounding effects of month of conception, child’s sex, gestation, parity and mean monthly temperature. Of the 522,896 eligible, singleton deliveries, 8,689 (1.66%) mothers developed pre-eclampsia. Total antenatal ultraviolet B exposure ranged from 43.18kJ/m2 to 101.11kJ/m2 and was associated with reduced risk of pre-eclampsia with evidence of a dose-response relationship (highest quintile of exposure: adjusted OR 0.57; 95% CI: 0.44, 0.72; p<0.001). Associations were demonstrated for ultraviolet B exposure in all three trimesters. Conclusions The seasonal patterning of pre-eclampsia may be mediated through low maternal vitamin D concentration in winter resulting from low ultraviolet B radiation. Interventional studies are required to determine whether vitamin D supplements, or ultraviolet B emitting light boxes, can reduce the seasonal patterning of pre-eclampsia.
This work was supported by Health Data Research UK [Edin-1 to CEH]. Provision of the UV data was funded by a joint Natural Environment Research Council, Medical Research Council and Chief Scientist Office project grant [ NE/P010911/1]; Tommy’s charity; and Health Data Research UK funding [Edin-1]. SJS is funded by Wellcome Trust Clinical Career Development Fellowship [ 209560/Z/17/Z].
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External DOI: https://doi.org/10.1161/jaha.120.020246
This record's URL: https://www.repository.cam.ac.uk/handle/1810/322921
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