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Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids.

Accepted version
Peer-reviewed

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Authors

Marsee, Ary 
Roos, Floris JM 
Verstegen, Monique MA 
HPB Organoid Consortium 
Gehart, Helmuth 

Abstract

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.

Description

Keywords

Delphi method, HPB, bile duct, epithelial organoid, gallbladder, liver, multi-organ organoid, multi-tissue organoid, pancreas, tumor organoid, Consensus, Liver, Organoids, Pancreas

Journal Title

Cell Stem Cell

Conference Name

Journal ISSN

1934-5909
1875-9777

Volume Title

28

Publisher

Elsevier BV
Sponsorship
National Centre for the Replacement Refinement and Reduction of Animals in Research (NC/R001162/1)
Medical Research Council (MC_PC_17230)
Medical Research Council (MR/R015635/1)