Human cytogenetics at Johns Hopkins Hospital, 1959-1962.
Accepted version
Peer-reviewed
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Repository DOI
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Authors
Ferguson-Smith, Malcolm A https://orcid.org/0000-0001-9372-1381
Abstract
An account is given of the introduction of human cytogenetics to the Division of Medical Genetics at Johns Hopkins Hospital, and the first 3 years' work of the chromosome diagnostic laboratory that was established at the time. Research on human sex chromosome disorders, including novel discoveries in the Turner and Klinefelter syndromes, is described together with original observations on chromosome behavior at mitosis. It is written in celebration of the centenary of the birth of Victor McKusick, the acknowledged father of Medical Genetics, who established the Division and had the foresight to ensure that it included the investigation of human chromosomes.
Description
Keywords
Klinefelter syndromes, Turner, X-inactivation, human chromosomes, Chromosome Aberrations, Cytogenetics, History, 20th Century, Hospitals, Humans, Klinefelter Syndrome, Sex Chromosome Aberrations, Sex Chromosome Disorders, Turner Syndrome
Journal Title
Am J Med Genet A
Conference Name
Journal ISSN
1552-4825
1552-4833
1552-4833
Volume Title
185
Publisher
Wiley