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dc.contributor.authorAbley, Katie
dc.contributor.authorFormosa-Jordan, Pau
dc.contributor.authorTavares, Hugo
dc.contributor.authorChan, Emily
dc.contributor.authorAfsharinafar, Mana
dc.contributor.authorLeyser, Ottoline
dc.contributor.authorLocke, James
dc.date.accessioned2021-06-03T23:30:14Z
dc.date.available2021-06-03T23:30:14Z
dc.date.issued2021-06-01
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/323326
dc.description.abstractGenetically identical plants growing in the same conditions can display heterogeneous phenotypes. Here we use Arabidopsis seed germination time as a model system to examine phenotypic variability and its underlying mechanisms. We show extensive variation in seed germination time variability between Arabidopsis accessions and use a multiparent recombinant inbred population to identify two genetic loci involved in this trait. Both loci include genes implicated in modulating abscisic acid (ABA) sensitivity. Mutually antagonistic regulation between ABA, which represses germination, and gibberellic acid (GA), which promotes germination, underlies the decision to germinate and can act as a bistable switch. A simple stochastic model of the ABA-GA network shows that modulating ABA sensitivity can generate the range of germination time distributions we observe experimentally. We validate the model by testing its predictions on the effects of exogenous hormone addition. Our work provides a foundation for understanding the mechanism and functional role of phenotypic variability in germination time.
dc.format.mediumElectronic
dc.languageeng
dc.publishereLife Sciences Publications, Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleAn ABA-GA bistable switch can account for natural variation in the variability of Arabidopsis seed germination time.
dc.typeArticle
prism.publicationDate2021
prism.publicationNameElife
prism.volume10
dc.identifier.doi10.17863/CAM.70784
dcterms.dateAccepted2021-03-01
rioxxterms.versionofrecord10.7554/eLife.59485
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-06
dc.contributor.orcidAbley, Katie [0000-0001-5524-6786]
dc.contributor.orcidFormosa-Jordan, Pau [0000-0003-3005-597X]
dc.contributor.orcidTavares, Hugo [0000-0001-9373-2726]
dc.contributor.orcidLeyser, Ottoline [0000-0003-2161-3829]
dc.contributor.orcidLocke, James [0000-0003-0670-1943]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idGatsby Charitable Foundation (unknown)
pubs.funder-project-idGatsby Charitable Foundation (GAT3395/PR1)
cam.issuedOnline2021-05-25


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International