Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Prins, Bram Peter https://orcid.org/0000-0001-5774-034X
Leitsalu, Liis https://orcid.org/0000-0001-7616-5440
Pärna, Katri https://orcid.org/0000-0002-0013-6077
Fischer, Krista https://orcid.org/0000-0002-3521-0599
Metspalu, Andres
Abstract
The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with the aim of prevention and individualized care. However, substantial efforts are required to realize the concept: enhanced genetic discoveries, translation into intervention strategies, and a systematic implementation in healthcare. Here we review how further genetic discoveries are improving personalized prediction and advance functional insights into the link between genetics and disease. In the second part we give our perspective on the way these advances in genomic research will transform the future of personalized prevention and medicine using Estonia as a primer.
Description
Keywords
Estonia, biobank, genetic discovery, genomic medicine, patient communication, return of results
Journal Title
J Pers Med
Conference Name
Journal ISSN
2075-4426
2075-4426
2075-4426
Volume Title
11
Publisher
MDPI AG
Publisher DOI
Sponsorship
Estonian Research Council grant PUT (PRG687, PRG555)
European Union through Horizon 2020 grant (633589, 777107)
British Heart Foundation (RG/18/13/33946, RG/13/13/30194)
Medical Research Council (MR/L003120/1)
European Union through Horizon 2020 grant (633589, 777107)
British Heart Foundation (RG/18/13/33946, RG/13/13/30194)
Medical Research Council (MR/L003120/1)